PolyCrit: An Online Collaborative Platform for Polymer Characterization

Polymer liquid chromatography at critical conditions (LCCC) is a chromatographic separation condition achieved by carefully balancing the interaction of a polymer with stationary and mobile phases to make the elution time of a polymer in chromatography independent of its molecular weight. By removing the dependence of elution time on polymer molecular weight, the LCCC then allows separation of polymer samples on the basis of secondary differences, such as topology, branching, and end-group functionality, that are otherwise difficult to resolve. Despite its potential, LCCC remains under-employed due to the complexity of its optimization and the scattered nature of existing data. To address these challenges, we developed PolyCrit, a database that organizes 428 critical chromatography conditions (characterized by 33 parameters) into a searchable and accessible online platform. PolyCrit centralizes decades of literature, providing detailed information on polymers, solvents, stationary phases, and chromatographic parameters. It features a quality scoring system to ensure data reliability and supports contributions from the research community through a validation process. By curating experimental critical conditions, PolyCrit reduces the need for extensive literature searches to utilize the powerful chromatographic technique. Additionally, PolyCrit invites current researchers to contribute to the database by submitting their own work. It can be found at https://lccc.ywangcomp.org.