Association of Type 2 Diabetes and Osteoarthritis: an Umbrella Review of Systematic Reviews and Meta-analyses

Overview

Journal Eur J Orthop Surg Traumatol

Specialty Orthopedics

Date 2025 Mar 12

PMID 40072698

Authors

Raju Vaishya

Anoop Misra

Mohit Kumar Patralekh

Pulkit Kalra

Abhishek Vaish

Filippo Migliorini

Affiliations

Soon will be listed here.

Abstract

Introduction: An association between type 2 diabetes and osteoarthritis has been postulated. The present umbrella review of systematic reviews and meta-analyses investigated possible bidirectional relationships between type 2 diabetes and osteoarthritis.

Methods: PubMed, Scopus, Web of Science, and Cochrane Library databases were accessed. All the available systematic reviews and meta-analyses on the relationship between type 2 diabetes and osteoarthritis were accessed. The odds ratio (OR) effect measure and 95% confidence interval (CI) were used for the statistical analyses.

Results: Four systematic reviews, of whom three meta-analyses, were considered. Data from 26209 patients with osteoarthritis were considered: 3530 with type 2 diabetes and 22679 without type 2 diabetes. A significantly increased rate of osteoarthritis was evidenced in patients with type 2 diabetes than in patients without it (OR = 1.43; 95% CI 1.01 to 2.02). The effect persisted after in the subgroups age, sex, and obesity (pooled adjusted OR = 1.22; 95% CI 1.05 to 1.42).

Conclusion: Patients with type 2 diabetes might present an increased risk of developing osteoarthritis.

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