Integrated Multi-biomarker Panel of CXCL13, HS-CRP, and WBC Counts Predicts Outcomes in Stroke Neurosyphilis Patients Treated with HBO and TUS-NMES

Overview

Journal Front Neurol

Specialty Neurology

Date 2025 Mar 12

PMID 40070668

Authors

Wenchao He

Shuangshuang Chen

Ruyang Chen

Jun Zhang

Xuehua Zhang

Minzhi Wu

Dan Zhang

Fengfeng Zhu

Fanghua He

Yating Xv

Na Lei

Wenhui Zheng

Xinyi Shan

Jun Dai

Affiliations

Soon will be listed here.

Abstract

Background: Neurosyphilis results from invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.

Objective: This study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.

Methods: The study included 158 neurosyphilis stroke patients treated from June 2022 to January 2024. Assessments of limb motor, cognitive functions, daily living abilities, and cerebrospinal fluid biomarkers were conducted pre- and post-four weeks of combined therapy.

Results: After treatment, there was a significant improvement in FMA, MoCA, and MBI scores ( < 0.001). CXCL13 levels significantly decreased post-treatment, correlating with improved patient outcomes. The study found strong predictive values for CXCL13 levels in determining the efficacy of rehabilitation, with the combination of CXCL13, WBC, and Hs-CRP showing the highest predictive accuracy.

Conclusion: HBO and TUS-NMES significantly enhance recovery in neurosyphilis stroke patients. CXCL13, WBC, and Hs-CRP effectively predict rehabilitation outcomes, highlighting their value in clinical management.

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