Molecular Hydrogen: Mechanism Against Oxidative Stress and Application in Periodontitis: A Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2025 Mar 11

PMID 40068089

Authors

Jiaxun Ying

Keran Zhang

Yangwen Huang

Xinyi Zhu

Yan Ruan

Haiyan Lin

Gang Wu

Affiliations

Soon will be listed here.

Abstract

Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydrogen's application in periodontitis. Finally, taking its treatment of periodontitis as an example, we develop an Essence-Necessity-Feasibility-Practice (ENFP) benefit evaluation model for whether to introduce new reagents in medical treatment and propose our conclusions on the application of molecular hydrogen before, during, and after periodontal surgeries.

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