Regulates Gut Microbiota and Increases the Effective Metabolite Luteolin to Inhibit MAPK/STAT3 Signaling Pathway to Alleviate Allergic Rhinitis

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2025 Mar 11

PMID 40066267

Authors

Mingyan Zhang

Xuewei Sun

Xiang Yu

Li Xu

Xinrui Zhang

Ruonan Zhang

Han Lu

Yujie Wang

Fei Xue

Ting Zhang

Chengliang Tang

Zihan Wu

Zhuohan Zhang

Jin Zhu

Qian Cui

Zhan Yang

You Cheng

Affiliations

Soon will be listed here.

Abstract

The global prevalence of allergic rhinitis (AR) remains high, posing challenges due to its chronic nature and propensity for recurrence. Gut microbiota dysbiosis contributes to immune dysregulation, impacting AR pathogenesis. () has great potential in regulating immune function to alleviate AR symptoms. However, the specific active components and mechanisms underlying its therapeutic effects in AR remain incompletely clarified. This study aimed to explore the potential mechanisms of and its metabolites in alleviating AR. The AR mouse model was constructed using ovalbumin (OVA). The analysis of hematoxylin-eosin staining (HE staining) and enzyme-linked immunosorbent assay (ELISA) suggested that alleviated nasal inflammation, suppressed aberrant Th2 immune responses, and modulated the balance of Treg and Th17 cytokines. The 16S rRNA sequencing and untargeted metabolic analysis revealed that restored gut microbiota composition and significantly increased the abundance of and the metabolite luteolin (LO). Through ELISA and Western blotting analysis, LO treatment restored the Th1/Th2 and Treg/Th17 cytokine balance and suppressed the MAPK/STAT3 signaling pathway in AR mice. The study highlights LO as a key metabolite contributing to the anti-inflammatory effects of , suggesting potential avenues for future therapeutic strategies in AR management.

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