Bibliometric and Visualisation Analyses of Gastric Ulcer Knowledge Areas and Emerging Trends, 2004-2024

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2025 Mar 10

PMID 40061369

Authors

Zijian Liu

Yi Liu

Yang Li

Yuyan Sun

Xiaoxiang Song

Lu Chen

Dan Zhou

Affiliations

Soon will be listed here.

Abstract

Background: Gastric ulcers are a form of peptic ulcers that present as ruptures of the mucosal lining of the stomach or the proximal intestinal lining extending beyond the muscularis mucosae, and infection is one of the main causative factors of gastric ulcers. However, the growing incidence of drug resistance and the emergence of specialised ulcers has necessitated continued research on gastric ulcers. This study surveyed global gastric ulcer research over the past two decades with the aim of identifying the major findings and emerging trends in the field.

Methods: Bibliometric analysis was performed using the search terms 'Gastric ulcer', 'Gastric ulcer disease', 'Gastrohelcoma', and 'Stomach ulcers'. Data were extracted from the Web of Science Core Database (WoSCC) and visualised using CiteSpace software.

Results: The Journal of Gastroenterology had the most cited papers. The largest number of papers was from the United States. The most frequently cited keywords were '', 'peptic ulcer', and 'gastric ulcer'.

Conclusion: The field of gastric ulcer research is rapidly expanding, and the existing research is focused on preventing the occurrence of gastric ulcers, exploring the pathogenesis of gastric ulcers, and identifying new methods of treating gastric ulcers.

References

Syn N, Cummings D, Wang L, Lin D, Zhao J, Loh M . Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants. Lancet. 2021; 397(10287):1830-1841. DOI: 10.1016/S0140-6736(21)00591-2. View

Martin-Nunez G, Cornejo-Pareja I, Clemente-Postigo M, Tinahones F . Gut Microbiota: The Missing Link Between Infection and Metabolic Disorders?. Front Endocrinol (Lausanne). 2021; 12:639856. PMC: 8247771. DOI: 10.3389/fendo.2021.639856. View

Arterburn D, Telem D, Kushner R, Courcoulas A . Benefits and Risks of Bariatric Surgery in Adults: A Review. JAMA. 2020; 324(9):879-887. DOI: 10.1001/jama.2020.12567. View

Khoder G, Al-Menhali A, Al-Yassir F, Karam S . Potential role of probiotics in the management of gastric ulcer. Exp Ther Med. 2016; 12(1):3-17. PMC: 4906699. DOI: 10.3892/etm.2016.3293. View

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M . Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001; 345(11):784-9. DOI: 10.1056/NEJMoa001999. View

Das A, Pereira V, Saxena S, Ghosh T, Anbumani D, Bag S . Gastric microbiome of Indian patients with Helicobacter pylori infection, and their interaction networks. Sci Rep. 2017; 7(1):15438. PMC: 5684312. DOI: 10.1038/s41598-017-15510-6. View

Lanas A, Chan F . Peptic ulcer disease. Lancet. 2017; 390(10094):613-624. DOI: 10.1016/S0140-6736(16)32404-7. View

Malfertheiner P, Chan F, McColl K . Peptic ulcer disease. Lancet. 2009; 374(9699):1449-61. DOI: 10.1016/S0140-6736(09)60938-7. View

Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M . Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options. J Clin Med. 2019; 8(2). PMC: 6406303. DOI: 10.3390/jcm8020179. View

10.

Scott D, Rex D, Melchers K, Sachs G . The effect of environmental pH on the proton motive force of Helicobacter pylori. Gastroenterology. 1996; 111(4):886-900. DOI: 10.1016/s0016-5085(96)70056-2. View

11.

Malmi H, Kautiainen H, Virta L, Farkkila N, Koskenpato J, Farkkila M . Incidence and complications of peptic ulcer disease requiring hospitalisation have markedly decreased in Finland. Aliment Pharmacol Ther. 2014; 39(5):496-506. DOI: 10.1111/apt.12620. View

12.

Xie Y, An L, Wang X, Ma Y, Bayoude A, Fan X . Protection effect of Dioscoreae Rhizoma against ethanol-induced gastric injury in vitro and in vivo: A phytochemical and pharmacological study. J Ethnopharmacol. 2024; 333:118427. DOI: 10.1016/j.jep.2024.118427. View

13.

Bardou M, Quenot J, Barkun A . Stress-related mucosal disease in the critically ill patient. Nat Rev Gastroenterol Hepatol. 2015; 12(2):98-107. DOI: 10.1038/nrgastro.2014.235. View

14.

Coblijn U, Lagarde S, de Castro S, Kuiken S, van Wagensveld B . Symptomatic marginal ulcer disease after Roux-en-Y gastric bypass: incidence, risk factors and management. Obes Surg. 2014; 25(5):805-11. DOI: 10.1007/s11695-014-1482-9. View

15.

Marshall B, Warren J . Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984; 1(8390):1311-5. DOI: 10.1016/s0140-6736(84)91816-6. View

16.

Bhattacharya S, Banerjee D, Bauri A, Chattopadhyay S, Bandyopadhyay S . Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action. World J Gastroenterol. 2007; 13(27):3705-13. PMC: 4250642. DOI: 10.3748/wjg.v13.i27.3705. View

17.

Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe S . Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014; 94(2):329-54. PMC: 4044300. DOI: 10.1152/physrev.00040.2012. View

18.

Park Y, Park K . Phytochemical Index and the Risk of Gastritis/Gastric Ulcer among Korean Adults: A Prospective Cohort Study. Nutrients. 2024; 16(15). PMC: 11314585. DOI: 10.3390/nu16152514. View

19.

Agagunduz D, Cocozza E, Cemali O, Bayazit A, Nani M, Cerqua I . Understanding the role of the gut microbiome in gastrointestinal cancer: A review. Front Pharmacol. 2023; 14:1130562. PMC: 9903080. DOI: 10.3389/fphar.2023.1130562. View

20.

Sinha M, Gautam L, Kumar Shukla P, Kaur P, Sharma S, Singh T . Current perspectives in NSAID-induced gastropathy. Mediators Inflamm. 2013; 2013:258209. PMC: 3610380. DOI: 10.1155/2013/258209. View