TRTBee: A Standalone Calculator for Time-Reinforced Toxicity According to EFSA Honeybee Guidelines

The revised European Food Safety Authority (EFSA) guidance document for the risk assessment of plant protection products on honeybees requires an assessment of time-reinforced toxicity (TRT) using toxicokinetic-toxicodynamic modelling. While there are user-friendly software options available for this modelling, it is not specialised for this new application, therefore conducting the TRT assessment still requires additional manual calculations. Here we present TRTBee: a new, freely available tool which is capable of automatically performing all stages of the TRT assessment. The tool is based on robust and well-known algorithms. We conclude with a brief discussion of the open problems that still exist within the EFSA scheme.