Emestrin-type Epipolythiodioxopiperazines from Aspergillus Nidulans with Cytotoxic Activities by Regulating PI3K/AKT and Mitochondrial Apoptotic Pathways

Overview

Journal Nat Prod Bioprospect

Publisher Springer

Specialty Biology

Date 2025 Mar 10

PMID 40059275

Authors

Pengkun Li

Qin Li

Aimin Fu

Yang Xiao

Chunmei Chen

Hucheng Zhu

Changxing Qi

Wei Wei

Yuan Zhou

Yonghui Zhang

Affiliations

Soon will be listed here.

Abstract

Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C-G (1-5), along with two known ETPs, prenylemestrin A (6) and prenylemestrin B (7), were obtained from Aspergillus nidulans. Their structures were characterized by spectroscopic data, X-ray crystallographic data, ECD comparisons and calculations. Prenylemestrins C-G (1 - 5) represent a rare class of ETPs, characterized by a 2,5-dithia-7,9-diazabicyclo[4.2.2]decane-8,10-dione core involving a hemiterpene moiety. Notably, compound 6 exhibited moderate cytotoxicity, inducing G2/M cell cycle arrest and apoptosis of L1210 cells by regulating the PI3K/AKT signaling pathway and mitochondrial apoptotic mechanisms.

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