Limitations of Radionuclide Ventriculography in the Non-invasive Diagnosis of Coronary Artery Disease. A Correlation with Right Heart Haemodynamic Values During Exercise

Overview

Journal Br Heart J

Specialty Cardiology & Vascular Diseases

Date 1985 Jun 1

PMID 4005082

Citations 4

Authors

S Wieshammer

C Delagardelle

H A Sigel

E Henze

P Kress

F BITTER

R Lippert

H Seibold

W E ADAM

M Stauch

Affiliations

Soon will be listed here.

Abstract

A consecutive series of 56 patients with chest pain but no evidence of previous myocardial infarction was prospectively studied by radionuclide ventriculography to determine the value of global and regional radionuclide indices in detecting coronary artery disease. The results were correlated with the clinical judgment of chest pain, the results of the exercise electrocardiogram, and the right heart haemodynamic measurements during exercise. As a result of the criteria for entry, the study group was representative of the population seen in such a clinical setting. Only 25% of patients had coronary artery disease. The predictive power of radionuclide ventriculography was limited. The conventionally used criterion that normal subjects have an increase in left ventricular ejection fraction of at least 5% with exercise provided only 78% sensitivity and 57% specificity. Fourier analysis and visual interpretation of radionuclide studies wrongly diagnosed three out of 10 patients with extensive disease requiring surgery. These results suggest that radionuclide ventriculography is of limited value in the non-invasive diagnosis of coronary artery disease.

Citing Articles

Left heart function in chronic obstructive lung disease.

Seibold H, Roth U, Lippert R, Kohler J, Wieshammer S, Henze E Klin Wochenschr. 1986; 64(9):433-41.

PMID: 3713112 DOI: 10.1007/BF01727529.

Radionuclide ventriculography and hemodynamic evaluation by right heart catheterization with exercise for assessing the functional significance of coronary artery stenoses. A comparative study.

Wieshammer S, Delagardelle C, SIGEL H, Henze E, Kress P, Keck F Klin Wochenschr. 1987; 65(12):571-5.

PMID: 3626425 DOI: 10.1007/BF01727625.

Radionuclide ventriculography (equilibrium gated blood pool scanning)--its present clinical position and recent developments.

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The detection of coronary artery disease: a comparison of exercise thallium imaging and exercise equilibrium radionuclide ventriculography.

McGhie I, Martin W, Tweddel A, Hutton I Eur J Nucl Med. 1987; 13(1):18-23.

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