A Report of Primary Pyogenic Ventriculitis Caused by Diagnosed by Metagenomic Next-Generation Sequencing

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2025 Mar 6

PMID 40046986

Authors

Dongdong Zhang

Minnan Deng

Fenfen Li

Ruile Shen

Affiliations

Soon will be listed here.

Abstract

Background: Primary ventriculitis is a rare but serious brain infection characterized by inflammation of the ependyma and purulence within the ventricular system. Due to the challenges in early diagnosis and the potential for suboptimal treatment, this condition carries a significant risk of complications such as recurrence, hydrocephalus, and death. Metagenomic next-generation sequencing (mNGS) enables the rapid and broad-spectrum identification of pathogens, facilitating timely and precise diagnosis.

Case Report: This study presents the first reported case of primary ventriculitis caused by . An 81-year-old female patient with hydrocephalus and clinical signs of central nervous system infection was diagnosed with primary ventriculitis based on brain magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis using mNGS. The patient underwent external ventricular drainage (EVD) and received a five-week course of ceftriaxone and linezolid. Following timely and targeted therapy, she demonstrated significant clinical improvement and was discharged without residual symptoms.

Conclusion: Key insights from this case include: 1) mNGS is an invaluable tool for the early and accurate diagnosis of primary ventriculitis; 2) MRI is indispensable for identifying characteristic radiological features of the condition; 3) prompt initiation and completion of appropriate antibiotic regimens significantly improve clinical outcomes.

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