Interventions for Suicidal and Self-injurious Related Behaviors in Adolescents with Psychiatric Disorders: a Systematic Review and Meta-analysis

Overview

Journal Transl Psychiatry

Specialties Psychiatry
Public Health

Date 2025 Mar 5

PMID 40044640

Authors

Junjie Lu

Jun Huang

Wanting Gao

Zexin Wang

Nan Yang

Yingbin Luo

Junxin Guo

Weng Ian Phoenix Pang

Grace Ka In Lok

Wenwang Rao

Affiliations

Soon will be listed here.

Abstract

As a leading cause of adolescent death, suicidal and self-injurious related behaviors (SSIRBs) is a devastating global health problem, particularly among patients with psychiatric disorders (PDs). Previous studies have shown that multiple interventions can alleviate symptoms and reduce risks. This review aimed to provide a systematic summary of interventions (i.e., medication, physical therapy, psychosocial therapy) for the treatment of SSIRBs among Chinese adolescents with PDs. From inception to September 17, 2023, twelve databases (PubMed, CINAHL, ScienceDirect, PsycINFO, EMBASE, Cochrane Library, Clinical Trial, Web of Science, CEPS, SinoMed, Wanfang and CNKI) were searched. We qualitatively and quantitatively synthesized the included studies. Standardized mean differences (SMDs), risk ratios and their 95% confidence intervals (CIs) used the Der Simonian and Laird random-effects model. Fifty-two studies covering 3709 eligible participants were included. Overall, the commonly used interventions targeting SSIRBs and negative feelings in PDs adolescents with SSIRBs included psychosocial therapy (e.g., cognitive behavioral therapy), medication (e.g., antidepressants), and physiotherapy (e.g., repetitive transcranial magnetic stimulation). Importantly, quetiapine fumarate in combination with sodium valproate (SV) had positive effects on reducing self-injury behaviors score [SMD: -2.466 (95% CI: -3.305, -1.628), I = 88.36%], depression [SMD: -1.587 (95% CI: -2.505, -0.670), I = 90.45%], anxiety [SMD: -1.925 (95% CI: -2.700, -1.150), I = 85.23%], impulsivity [SMD: -2.439 (95% CI: -2.748, -2.094), I = 0%], as well as its safety in comparison with SV alone. No significant difference of adverse reactions was found by low-dose QF (P > 0.05). This review systematically outlined the primary characteristics, safety and effectiveness of interventions for Chinese PDs adolescents with SSIRBs, which could serve as valuable evidence for guidelines aiming to formulate recommendations.

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