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A Case of Induction Chemoimmunotherapy and Sleeve Lobectomy to Avoid Pneumonectomy for Central Squamous Cell Lung Cancer

Overview
Journal Surg Case Rep
Specialty General Surgery
Date 2025 Mar 5
PMID 40040629
Authors
Ayaka Asakawa
Ryota Ishizawa
Yukitaka Sato
Yuya Ishikawa
Ryo Wakejima
Hironori Ishibashi
Kenichi Okubo
Affiliations
Soon will be listed here.
Abstract

Introduction: Recently, neoadjuvant immunotherapy plus chemotherapy has been provided for patients with stage II-III resectable lung cancer. We report a case in which a pneumonectomy was avoided by administrating neoadjuvant chemoimmunotherapy.

Case Presentation: An 81-year-old man presented with a cough. Examination showed squamous cell lung cancer in the right lower lobe extending to the central side of the upper lobe, which would have required a pneumonectomy for complete resection. Neoadjuvant chemoimmunotherapy was administered to reduce the extent of pulmonary resection due to the patient's advanced age and impaired pulmonary function. Post-treatment examination showed tumor size reduction, and bronchoscopy showed disappearance of right upper bronchial erythema and persistent erythema of the bronchus intermedius. A sleeve right lower lobectomy was performed. Histopathological findings revealed complete resection of the cancerous lesion and a major pathological response.

Conclusions: Sleeve lobectomy after preoperative chemoimmunotherapy for an elder patient with low pulmonary function was safe and efficient.

References
1.
Mitsudomi T, Ito H, Okada M, Sugawara S, Shio Y, Tomii K . Neoadjuvant nivolumab plus chemotherapy in resectable non-small-cell lung cancer in Japanese patients from CheckMate 816. Cancer Sci. 2023; 115(2):540-554. PMC: 10859619. DOI: 10.1111/cas.16030. View
2.
Nomori H, Cong Y, Sugimura H . Preceding bronchial cutting for exposure of the pulmonary artery buried in scar tissue after chemoradiotherapy. Gen Thorac Cardiovasc Surg. 2016; 65(1):67-70. DOI: 10.1007/s11748-015-0618-8. View
3.
Broderick S, Patel A, Crabtree T, Bell J, Morgansztern D, Robinson C . Pneumonectomy for Clinical Stage IIIA Non-Small Cell Lung Cancer: The Effect of Neoadjuvant Therapy. Ann Thorac Surg. 2015; 101(2):451-7. PMC: 4718846. DOI: 10.1016/j.athoracsur.2015.07.022. View
4.
Li J, Zu P, Jakopovic M, Legras A, Saji H, Onodera K . A case report of cStage IIIB squamous cell lung carcinoma completely resected after downstaging with neoadjuvant therapy. J Thorac Dis. 2024; 16(5):3503-3511. PMC: 11170368. DOI: 10.21037/jtd-24-522. View
5.
Romero Roman A, Campo-Canaveral de la Cruz J, Macia I, Escobar Campuzano I, Figueroa Almanzar S, Delgado Roel M . Outcomes of surgical resection after neoadjuvant chemoimmunotherapy in locally advanced stage IIIA non-small-cell lung cancer. Eur J Cardiothorac Surg. 2021; 60(1):81-88. DOI: 10.1093/ejcts/ezab007. View