Research Status of Biomaterials Based on Physical Signals for Bone Injury Repair

Overview

Journal Regen Ther

Date 2025 Mar 3

PMID 40027992

Authors

Qi Sun

Chao-Hua Li

Qi-Shun Liu

Yuan-Bin Zhang

Bai-Song Hu

Qi Feng

Yong Lang

Affiliations

Soon will be listed here.

Abstract

Bone defects repair continues to be a significant challenge facing the world. Biological scaffolds, bioactive molecules, and cells are the three major elements of bone tissue engineering, which have been widely used in bone regeneration therapy, especially with the rise of bioactive molecules in recent years. According to their physical properties, they can be divided into force, magnetic field (MF), electric field (EF), ultrasonic wave, light, heat, etc. However, the transmission of bioactive molecules has obvious shortcomings that hinder the development of the tissue-rearing process. This paper reviews the mechanism of physical signal induction in bone tissue engineering in recent years. It summarizes the application strategies of physical signal in bone tissue engineering, including biomaterial designs, physical signal loading strategies and related pathways. Finally, the ongoing challenges and prospects for the future are discussed.

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