Emerging Brain Organoids: 3D Models to Decipher, Identify and Revolutionize Brain

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2025 Mar 3

PMID 40026825

Authors

Yuli Zhao

Ting Wang

Jiajun Liu

Ze Wang

Yuan Lu

Affiliations

Soon will be listed here.

Abstract

Brain organoids are an emerging 3D brain model that is integrated from pluripotent stem cells. This model mimics the human brain's developmental process and disease-related phenotypes to a certain extent while advancing the development of human brain-based biological intelligence. However, many limitations of brain organoid culture (e.g., lacking a functional vascular system, etc.) prevent -cultured organoids from truly replicating the human brain in terms of cell type and structure. To improve brain organoids' scalability, efficiency, and stability, this paper discusses important contributions of material biology and microprocessing technology in solving the related limitations of brain organoids and applying the latest imaging technology to make real-time imaging of brain organoids possible. In addition, the related applications of brain organoids, especially the development of organoid intelligence combined with artificial intelligence, are analyzed, which will help accelerate the rational design and guidance of brain organoids.

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