CCL11 (Eotaxin) Promotes the Advancement of Aging-Related Cardiovascular Diseases

Overview

Journal Rev Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2025 Mar 3

PMID 40026499

Authors

Tanwei Zhang

Yanhong Huang

Xinmeng Ji

Teng Wu

Pingxi Xiao

Affiliations

Soon will be listed here.

Abstract

Aging-related diseases, such as cardiovascular diseases (CVDs), neurodegeneration, cancer, etc., have become important factors that threaten the lifespans of older individuals. A chronic inflammatory response is closely related to aging-related diseases. Establishing inflammatory aging clock (iAGE, deep-learning methods on blood immune biomarkers to construct a metric for age-related chronic inflammation) successfully predicted the positive correlation between several factors, including serum C-C-motif chemokine ligand 11 (CCL11) and aging-related diseases. Recently, the role and mechanism of CCL11, an eosinophilic chemokine, in neurodegenerative diseases have been widely reported. Additionally, many research studies have shown a positive correlation with CVDs, but the underlying mechanism remains unknown. This review focuses on the relationship between chronic inflammation and aging. The role of CCL11 will be discussed and summarized in relation to aging-related diseases, especially CVDs.

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