AgRP Neurons Shape the Sperm Small RNA Payload

Overview

Journal Sci Rep

Specialty Science

Date 2025 Feb 28

PMID 40021730

Authors

Iasim Tahiri

Sergio R Llana

Francisco Diaz-Castro

Marc Claret

Arnaud Obri

Affiliations

Soon will be listed here.

Abstract

Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons in mice to simulate obesity's effects, we observed changes in the small noncoding RNA payload of sperm. These alterations, particularly in transfer RNA-derived small RNAs (tsRNAs), are similar to those induced by short-term high-fat diets, suggesting a common upstream regulatory mechanism involving AgRP neurons that affects metabolic epigenetic inheritance.

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