Neuroimaging Advances in Neurocognitive Disorders Among HIV-infected Individuals

Overview

Journal Front Neurol

Specialty Neurology

Date 2025 Feb 28

PMID 40017532

Authors

Han Wang

Xiaolin Jiu

Zihua Wang

Yanwei Zhang

Affiliations

Soon will be listed here.

Abstract

Although combination antiretroviral therapy (cART) has been widely applied and effectively extends the lifespan of patients infected with human immunodeficiency virus (HIV), these patients remain at a substantially increased risk of developing neurocognitive impairment, commonly referred to as HIV-associated neurocognitive disorders (HAND). Magnetic resonance imaging (MRI) has emerged as an indispensable tool for characterizing the brain function and structure. In this review, we focus on the applications of various MRI-based neuroimaging techniques in individuals infected with HIV. Functional MRI, structural MRI, diffusion MRI, and quantitative MRI have all contributed to advancing our comprehension of the neurological alterations caused by HIV. It is hoped that more reliable evidence can be achieved to fully determine the driving factors of cognitive impairment in HIV through the combination of multi-modal MRI and the utilization of more advanced neuroimaging analysis methods.

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