Adiponectin C1Q and Collagen Domain Containing Rs266729, Cyclin-Dependent Kinase Inhibitor 2A and 2B Rs10811661, and Signal Sequence Receptor Subunit 1 Rs9505118 Polymorphisms and Their Association with Gestational Diabetes Mellitus: A Case-Control...

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Feb 26

PMID 40004118

Authors

Mihai Muntean

Claudiu Marginean

Elena Silvia Bernad

Claudia Banescu

Victoria Nyulas

Irina Elena Muntean

Vladut Sasaran

Affiliations

Soon will be listed here.

Abstract

Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) are public health concerns worldwide. These two diseases share the same pathophysiological and genetic similarities. This study aimed to investigate the T2DM known single nucleotide polymorphisms (SNPs) of the adiponectin C1Q and collagen domain containing (), cyclin-dependent kinase inhibitor 2A and 2B (), and signal sequence receptor subunit 1 () genes in a cohort of Romanian GDM pregnant women and perinatal outcomes. DNA was isolated from the peripheral blood of 213 pregnant women with = 71) or without ( = 142) GDM. Afterward, (rs266729), (rs10811661), and (rs9505118) gene polymorphisms were genotyped using TaqMan Real-Time PCR analysis. Women with GDM had a higher pre-pregnancy body mass index (BMI) ( < 0.0001), higher BMI ( < 0.0001), higher insulin resistance homeostatic model assessment (IR-HOMA) ( = 0.0002), higher insulin levels ( = 0.003), and lower adiponectin levels ( = 0.004) at birth compared to pregnant women with normoglycemia. GDM pregnant women had gestational hypertension (GH) more frequently during pregnancy ( < 0.0001), perineal lacerations more frequently during vaginal birth ( = 0.03), and more macrosomic newborns ( < 0.0001) than pregnant women from the control group. We did not find an association under any model (allelic, genotypic, dominant, or recessive) of rs266729, rs10811661, and rs9505118 polymorphisms and GDM. In correlation analysis, we found a weak positive correlation (r = 0.24) between the dominant model GG + CG vs. CC of rs266729 and labor induction failure. In the dominant model TT vs. CC + CT of rs10811661, we found a weak negative correlation between this model and perineal lacerations. Our results suggest that the rs266729, the rs10811661, and the rs9505118 gene polymorphisms are not associated with GDM in a cohort of Romanian pregnant women.

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