Bioinformatic Selection of Mannose-Specific Lectins from As SARS-CoV-2 Inhibitors Analysing Protein-Protein Interaction

Overview

Journal Life (Basel)

Specialty Biology

Date 2025 Feb 26

PMID 40003571

Authors

Stefan Isakovic

Milan Sencanski

Vladimir Perovic

Kristina Stevanovic

Ivana Prodic

Affiliations

Soon will be listed here.

Abstract

Mannose-specific lectins are carbohydrate-binding proteins known for their antiviral potential. This study uses a bioinformatic approach to investigate the possibility of lectins from (garlic) and (wild garlic) as inhibitors of SARS-CoV-2 entry. The information spectrum method (ISM) identified key interaction frequencies between the SARS-CoV-2 spike protein and these lectins, explicitly targeting the receptor-binding domain (RBD) and glycosylated asparagine residues, including N234. Lectins from species showed a high affinity for oligomannose-type glycans on the spike protein, potentially blocking virus entry by preventing the spike-ACE2 receptor interaction. We propose that Allium lectins are promising candidates for further experimental validation as SARS-CoV-2 inhibitors, offering potential therapeutic applications in managing viral infections.

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