Protective Effects of Atractylodis Rhizoma Extracts on Lung Injury Induced by Particulate Matter 2.5 in Mice

Overview

Journal Antioxidants (Basel)

Date 2025 Feb 26

PMID 40002314

Authors

Eun-Hee Yun

Khawaja Muhammad Imran Bashir

Jeongjun Lee

Hunsuk Chung

Young-Sam Kwon

Jae-Suk Choi

Sae-Kwang Ku

Affiliations

Soon will be listed here.

Abstract

This study investigated the lung-protective effects of Atractylodis Rhizoma extracts (the root of Koidz. ex Kitam), known as AJ extracts, in mitigating subacute pulmonary injuries caused by particulate matter 2.5 (PM) exposure in Balb/c mice. AJ was given orally at concentrations of 400, 200, and 100 mg/kg, demonstrating a promising impact by mitigating oxidative stress and inflammation associated with phosphoinositide 3-kinase/protein kinase B () and p38 mitogen-activated protein kinase α () pathways and reducing mucus overproduction. These protective effects were achieved through the downregulation of and mRNA expressions, enhanced anti-inflammatory and antioxidant activities, and increased mucolytic expectorant effects arbitrated by elevated lung acetylcholine (ACh) and substance P levels, along with decreased mRNA expressions of and . Importantly, these outcomes occurred without significant hepatotoxicity. While all AJ dosages provided dose-dependent pulmonary protection, their effects were less pronounced than those of dexamethasone (DEXA) at 0.75 mg/kg. However, AJ uniquely exhibited mucolytic expectorant activities absent in DEXA-treated mice. The results indicate that may serve as a potential candidate for creating alternative treatments for respiratory conditions or as an ingredient in functional foods.

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