» Articles » PMID: 39998770

Insulin Resistance and Estimated 10-Year Risk of a First Hard Cardiovascular Event

Overview
Journal Curr Med Sci
Specialty General Medicine
Date 2025 Feb 25
PMID 39998770
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: This study aimed to investigate the association between insulin resistance and the risk of cardiovascular disease.

Methods: A cross-sectional study including 2128 participants aged 40-79 years was conducted using data from the National Health and Nutrition Examination Survey from 1999 to 2018. The quantitative insulin sensitivity check index (QUICKI) and homeostasis model assessment of β-cell function (HOMA-β) were used as independent variables. The 10-year risk of a first hard atherosclerotic cardiovascular event was used as the dependent variable, with other potential confounding factors considered. Multivariate linear regression models and smooth curve fitting were used to assess the associations between insulin resistance and 10-year risk.

Results: A total of 2128 patients, comprising 1191 men and 937 women, were included in our analysis. The regression analyses revealed a negative correlation between the QUICKI score and the 10-year risk of a first hard atherosclerotic cardiovascular event [β = - 8.85, CI (- 15.77, - 1.93)] after adjusting for age, race, body mass index, systolic blood pressure, diastolic blood pressure, hypertension treatment, smoking, diabetes, and low-density lipoprotein cholesterol. Conversely, an increase in HOMA-β was associated with 10-year risk [β =  6.84, CI (0.45, 13.23)]. Gender-specific subgroup analysis indicated that the QUICKI had a β value of 0.077 (0.046, 0.108) for men and 0.080 (0.061, 0.094) for women.

Conclusion: This study demonstrated that increased insulin resistance is linked to an increased risk of cardiovascular disease.

References
1.
Lee S, Park S, Choi C . Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes Metab J. 2021; 46(1):15-37. PMC: 8831809. DOI: 10.4093/dmj.2021.0280. View

2.
Adeva-Andany M, Martinez-Rodriguez J, Gonzalez-Lucan M, Fernandez-Fernandez C, Castro-Quintela E . Insulin resistance is a cardiovascular risk factor in humans. Diabetes Metab Syndr. 2019; 13(2):1449-1455. DOI: 10.1016/j.dsx.2019.02.023. View

3.
Hill M, Yang Y, Zhang L, Sun Z, Jia G, Parrish A . Insulin resistance, cardiovascular stiffening and cardiovascular disease. Metabolism. 2021; 119:154766. DOI: 10.1016/j.metabol.2021.154766. View

4.
Marusic M, Paic M, Knobloch M, Liberati Prso A . NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2. Can J Gastroenterol Hepatol. 2021; 2021:6613827. PMC: 7904371. DOI: 10.1155/2021/6613827. View

5.
Liang C, Han S, Senokuchi T, Tall A . The macrophage at the crossroads of insulin resistance and atherosclerosis. Circ Res. 2007; 100(11):1546-55. DOI: 10.1161/CIRCRESAHA.107.152165. View