Self-Supported Cu/FeO Hierarchical Nanosheets on Ni Foam for High-Efficiency Non-Enzymatic Glucose Sensing

Overview

Journal Nanomaterials (Basel)

Date 2025 Feb 25

PMID 39997844

Authors

Jing Xu

Hairui Cai

Ke Yu

Jie Hou

Zhuo Li

Xiaoxiao Zeng

Huijie He

Xiaojing Zhang

Di Su

Shengchun Yang

Affiliations

Soon will be listed here.

Abstract

Electrochemical glucose sensors are vital for clinical diagnostics and the food industry, where accurate detection is essential. However, the limitations of glucose oxidase (GOx)-based sensors, such as complex preparation, high cost, and environmental sensitivity, highlight the need for non-enzymatic sensors that directly oxidize glucose at the electrode surface. In this study, a self-supporting hierarchical Cu/FeO nanosheet electrode was successfully fabricated by in situ growth on Ni Foam using a hydrothermal method, followed by annealing treatment. The Cu/FeO hierarchical nanosheet structure, with its large surface area, provides abundant active sites for electrocatalysis, while the strong interactions between Cu/FeO and Ni Foam enhance electron transfer efficiency. This novel electrode structure demonstrates exceptional electrochemical performance for non-enzymatic glucose sensing, with an ultrahigh sensitivity of 12.85 μA·μM·cm, a low detection limit of 0.71 μM, and a linear range extending up to 1 mM. Moreover, the Cu/FeO/NF electrode exhibits excellent stability, a rapid response (~3 s), and good selectivity against interfering substances such as uric acid, ascorbic acid, HO, urea, and KCl. It also shows strong reliability in analyzing human serum samples. Therefore, Cu/FeO/NF holds great promise as a non-enzymatic glucose sensor, and this work offers a valuable strategy for the design of advanced electrochemical electrodes.

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