Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques

Overview

Journal Infect Dis Rep

Publisher MDPI

Specialty Infectious Diseases

Date 2025 Feb 25

PMID 39997464

Authors

Julien A Clain

Morgane Picard

Henintsoa Rabezanahary

Sonia Andre

Steven Boutrais

Ella Goma Matsetse

Juliette Dewatines

Quentin Dueymes

Elise Thiboutot

Gina Racine

Calaiselvy Soundaramourty

Fabrizio Mammano

Pierre Corbeau

Ouafa Zghidi-Abouzid

Jerome Estaquier

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection.

Methods: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure.

Results: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV.

Conclusions: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.

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