Meroterpenoids from Terrestrial and Marine Fungi: Promising Agents for Neurodegenerative Disorders-An Updated Review

Overview

Journal Curr Issues Mol Biol

Publisher MDPI

Specialty Molecular Biology

Date 2025 Feb 25

PMID 39996817

Authors

Daniela Dimitrova

Simeonka Dimitrova

Gabriela Kehayova

Stela Dragomanova

Affiliations

Soon will be listed here.

Abstract

Background: Meroterpenoids represent a remarkably diverse class of natural secondary metabolites, some of which are synthesized via terpenoid biosynthetic pathways. Over the past ten years, these compounds have gained interest because of their wide range of biological activities, such as anti-cholinesterase, COX-2 inhibitory, antibacterial, antiviral, antidiabetic, antioxidant, anti-inflammatory, antineoplastic, and cardioprotective properties. This review aims to consolidate the recognized neuroprotective effects of meroterpenoids from marine and terrestrial fungi.

Methods: Data compiled from several databases, including PubMed, Science Direct, Scopus, and Google Scholar, include articles published since 2000 using keywords such as "neuroprotective", "fungi", "mushroom", "marine sponge", "neurodegeneration", and "dementia" in connection with "meroterpenoids".

Results: Meroterpenoids modulate different cell signaling pathways and exhibit different and often combined mechanisms of action to ameliorate neuronal damage and dysfunction. Reported activities include anti-cholinesterase, antioxidant, BACE1 inhibition, and anti-inflammatory activities, all of which have potential in the treatment of dementia associated with neurodegenerative diseases such as Alzheimer's and Parkinson's.

Conclusions: Meroterpenoids have the potential to be developed as effective tools for neuropathological diseases. Ongoing research to elucidate the various neuroprotective pathways remains essential and requires further investigation.

References

Gao S, Zhang P, Zhang C, Bao F, Li H, Chen L . Meroterpenoids from Ganoderma sinense protect hepatocytes and cardiomyocytes from oxidative stress induced injuries. Fitoterapia. 2018; 131:73-79. DOI: 10.1016/j.fitote.2018.10.009. View

Peng X, Li L, Wang X, Zhu G, Li Z, Qiu M . Antioxidant farnesylated hydroquinones from Ganoderma capense. Fitoterapia. 2016; 111:18-23. DOI: 10.1016/j.fitote.2016.04.006. View

Sengupta U, Nilson A, Kayed R . The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy. EBioMedicine. 2016; 6:42-49. PMC: 4856795. DOI: 10.1016/j.ebiom.2016.03.035. View

Kou R, Xia B, Wang Z, Li J, Yang J, Gao Y . Triterpenoids and meroterpenoids from the edible Ganoderma resinaceum and their potential anti-inflammatory, antioxidant and anti-apoptosis activities. Bioorg Chem. 2022; 121:105689. DOI: 10.1016/j.bioorg.2022.105689. View

Flora S . Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev. 2010; 2(4):191-206. PMC: 2763257. DOI: 10.4161/oxim.2.4.9112. View

Orobets K, Karamyshev A . Amyloid Precursor Protein and Alzheimer's Disease. Int J Mol Sci. 2023; 24(19). PMC: 10573485. DOI: 10.3390/ijms241914794. View

Butterfield D, Di Domenico F, Swomley A, Head E, Perluigi M . Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J. 2014; 463(2):177-89. PMC: 4686233. DOI: 10.1042/BJ20140772. View

Jiao W, Shi G, Xu T, Chen G, Gu B, Wang Z . Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge. J Nat Prod. 2016; 79(2):406-11. DOI: 10.1021/acs.jnatprod.5b01079. View

El-Demerdash A, Kumla D, Kijjoa A . Chemical Diversity and Biological Activities of Meroterpenoids from Marine Derived-Fungi: A Comprehensive Update. Mar Drugs. 2020; 18(6). PMC: 7345968. DOI: 10.3390/md18060317. View

10.

Qi B, Liu X, Mo T, Zhu Z, Li J, Wang J . 3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata. J Nat Prod. 2017; 80(10):2699-2707. DOI: 10.1021/acs.jnatprod.7b00438. View

11.

Simon-Levert A, Menniti C, Soulere L, Geneviere A, Barthomeuf C, Banaigs B . Marine natural meroterpenes: synthesis and antiproliferative activity. Mar Drugs. 2010; 8(2):347-58. PMC: 2852842. DOI: 10.3390/md8020347. View

12.

Gui Y, Jiao W, Zhou M, Zhang Y, Zeng D, Zhu H . Septosones A-C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa. Org Lett. 2019; 21(3):767-770. DOI: 10.1021/acs.orglett.8b04019. View

13.

Jiao W, Cheng B, Shi G, Chen G, Gu B, Zhou Y . Dysivillosins A-D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa. Sci Rep. 2017; 7(1):8947. PMC: 5567184. DOI: 10.1038/s41598-017-04021-z. View

14.

Lee S, Hsu J, Chen T, Huang C, Wu T, Chin T . Erinacine A Prevents Lipopolysaccharide-Mediated Glial Cell Activation to Protect Dopaminergic Neurons against Inflammatory Factor-Induced Cell Death In Vitro and In Vivo. Int J Mol Sci. 2022; 23(2). PMC: 8776144. DOI: 10.3390/ijms23020810. View

15.

Shevchuk Y, Kuypers K, Janssens G . Fungi as a source of bioactive molecules for the development of longevity medicines. Ageing Res Rev. 2023; 87:101929. DOI: 10.1016/j.arr.2023.101929. View

16.

Chen C, Tzeng T, Chen C, Ni C, Lee L, Chen W . Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus. J Nat Prod. 2016; 79(2):438-41. DOI: 10.1021/acs.jnatprod.5b00474. View

17.

Johnson S, Fang T, De Marchi F, Neel D, Van Weehaeghe D, Berry J . Pharmacotherapy for Amyotrophic Lateral Sclerosis: A Review of Approved and Upcoming Agents. Drugs. 2022; 82(13):1367-1388. DOI: 10.1007/s40265-022-01769-1. View

18.

Lian W, Yang X, Duan Q, Li J, Zhao Y, Yu C . The Biological Activity of on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks. Molecules. 2024; 29(11). PMC: 11173733. DOI: 10.3390/molecules29112516. View

19.

Li H, Sun W, Deng M, Qi C, Chen C, Zhu H . Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus . Mar Drugs. 2018; 16(6). PMC: 6025407. DOI: 10.3390/md16060177. View

20.

Fierro F, Vaca I, Castillo N, Garcia-Rico R, Chavez R . , a Vintage Model with a Cutting-Edge Profile in Biotechnology. Microorganisms. 2022; 10(3). PMC: 8954384. DOI: 10.3390/microorganisms10030573. View