A Review of the Modified Multiplier of SES-CD (MM-SES-CD) and How to Use in Clinical Trials and Practice

Endoscopic evaluation is valuable in the diagnosis, assessment, and management of Crohn's Disease. The Simple Endoscopic Score for Crohn's Disease (SES-CD) was created using a uniform, linear scoring scale of 0-3 for each of its four parameters at five anatomical locations and was designed to accurately indicate disease severity rather than predict disease progression. There is evidence to suggest all disease segments and parameters of the SES-CD do not have equal prognostic value for likelihood of achieving endoscopic remission (ER). The Modified Multiplier Simple Endoscopic Score for Crohn's Disease (MM-SES-CD), developed by multivariable logistic regression modelling, weighs the individual parameters of the SES-CD including disease distribution based on their prognostic values for achieving ER. The objective of this qualitative review is to provide guidance to clinicians and clinical trialists for how to use and interpret the MM-SES-CD.