The Weight-adjusted-waist Index Predicts All-cause and Cardiovascular Mortality in Hypertension

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2025 Feb 25

PMID 39995963

Authors

Yu Zheng

Zixing Nie

Yifan Zhang

Tao Sun

Affiliations

Soon will be listed here.

Abstract

Background: Weight-adjusted-waist (WWI) is a novel indicator of obesity that reflects the degree of central obesity in the human body.

Objectives: The study aimed to explore the relationship between WWI and mortality in hypertensive individuals.

Methods: Cross-sectional data from the 2001-2018 National Health and Nutrition Examination Survey (NHANES) dataset were used in this study. The relationship between WWI and mortality was assessed using a weighted Cox proportional risk model; the nonlinear relationship was explored using restricted cubic splines. The robustness of the results was verified by subgroup and sensitivity analyses.

Results: A cohort of 11,556 people with a diagnosis of hypertension was included in this study. As a continuous variable, WWI was linked to higher rates of mortality from all-cause (HR = 1.23, 95% CI = 1.14, 1.33) and cardiovascular disease (CVD) (HR = 1.43, 95% CI = 1.23, 1.66) with hypertension in Model 3 adjusted for variables. Using WWI as a tertile categorical variable, individuals in the highest tertile had a 33% higher risk of all-cause death (HR = 1.33, 95% CI = 1.14, 1.56) and a 65% higher risk of CVD death (HR = 1.65, 95% CI = 1.19, 2.27) than individuals in the lowest tertile. According to the subgroup analysis, almost all groups showed a consistent positive correlation between WWI and mortality related to all-cause and CVD.

Conclusion: In adults with hypertension, there is a positive association between WWI and all-cause and CVD mortality.

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