Insulin Autoimmune Syndrome: A Chinese Expert Consensus Statement

Overview

Journal Aging Med (Milton)

Specialty Geriatrics

Date 2025 Feb 24

PMID 39990629

Authors

Huabing Zhang

Ming Xia Yuan

Qi Pan

Affiliations

Soon will be listed here.

Abstract

Insulin autoimmune syndrome (IAS) is a rare autoimmune disorder characterized by spontaneous hypoglycemia. The incidence of IAS is higher in East Asian populations compared to other populations. Delayed diagnosis and treatment can lead to recurrent hypoglycemia, significant glucose fluctuations, and adverse clinical outcomes, including life-threatening situations. Currently, no standardized guidelines exist for the diagnosis and treatment of IAS. This consensus aims to provide a systematic summary of the epidemiology, triggers, pathogenesis, clinical manifestations, diagnosis, differential diagnosis, treatment, and prognosis of IAS, with the objective of standardizing its clinical management.

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