Developmental Lead Exposure and Aggression in Male Rats: Influences of Maternal Care and Environmental Enrichment

Overview

Journal Toxicol Rep

Date 2025 Feb 24

PMID 39989979

Authors

Shamaila Zafar

Courtney Williams

Jaehyun Joo

Blanca E Himes

Jay S Schneider

Affiliations

Soon will be listed here.

Abstract

Developmental lead (Pb) exposure results in a variety of cognitive deficits and behavioral issues including increased antisocial behavior and aggression. This study investigated the effect of developmental Pb exposure on aggression and violent behavior in male rats and the potential modulatory influences of quality of maternal care and enriched/non-enriched housing conditions. Long-Evans male rats with or without Pb exposure (perinatal or early postnatal) from low or high maternal care mothers (based on amounts of licking/grooming and arched-back nursing) were randomly assigned to live in enriched or non-enriched environments at weaning. At postnatal day 120-190, offensive aggression was assessed using a resident intruder test. Clinch attack (CAK) frequency and latency, and occurrence of biting events were observed to determine violent behavior. Both perinatal and postnatal Pb-exposed rats were significantly more aggressive and showed more violent behavior, compared to non-Pb-exposed animals, regardless of level of maternal care and environmental enrichment. High maternal care significantly lowered the proportion of animals with short CAK latencies and enriched housing significantly lowered the occurrence of biting events. These results suggest that high maternal care and enriched housing may potentially modify expression of violent aggressive behavior in rats with early life Pb exposure.

References

Cardenas-Iniguez C, Burnor E, Herting M . Neurotoxicants, the Developing Brain, and Mental Health. Biol Psychiatry Glob Open Sci. 2022; 2(3):223-232. PMC: 9337627. DOI: 10.1016/j.bpsgos.2022.05.002. View

Delville Y . Exposure to lead during development alters aggressive behavior in golden hamsters. Neurotoxicol Teratol. 1999; 21(4):445-9. DOI: 10.1016/s0892-0362(98)00062-2. View

Li W, Han S, Gregg T, Kemp F, Davidow A, Louria D . Lead exposure potentiates predatory attack behavior in the cat. Environ Res. 2003; 92(3):197-206. DOI: 10.1016/s0013-9351(02)00083-x. View

Kaffman A, Meaney M . Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. J Child Psychol Psychiatry. 2007; 48(3-4):224-44. DOI: 10.1111/j.1469-7610.2007.01730.x. View

Naicker N, de Jager P, Naidoo S, Mathee A . Is There a Relationship between Lead Exposure and Aggressive Behavior in Shooters?. Int J Environ Res Public Health. 2018; 15(7). PMC: 6068756. DOI: 10.3390/ijerph15071427. View

Schwaba T, Bleidorn W, Hopwood C, Gebauer J, Rentfrow P, Potter J . The impact of childhood lead exposure on adult personality: Evidence from the United States, Europe, and a large-scale natural experiment. Proc Natl Acad Sci U S A. 2021; 118(29). PMC: 8307752. DOI: 10.1073/pnas.2020104118. View

Koolhaas J, Coppens C, de Boer S, Buwalda B, Meerlo P, Timmermans P . The resident-intruder paradigm: a standardized test for aggression, violence and social stress. J Vis Exp. 2013; (77):e4367. PMC: 3731199. DOI: 10.3791/4367. View

Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, FREEDMAN A . Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997; 277(5332):1659-62. DOI: 10.1126/science.277.5332.1659. View

Cervantes M, David J, Loyd D, Salinas J, Delville Y . Lead exposure alters the development of agonistic behavior in golden hamsters. Dev Psychobiol. 2005; 47(2):158-65. DOI: 10.1002/dev.20076. View

10.

Haller J, Halasz J, Mikics E, Kruk M, Makara G . Ultradian corticosterone rhythm and the propensity to behave aggressively in male rats. J Neuroendocrinol. 2000; 12(10):937-40. DOI: 10.1046/j.1365-2826.2000.00568.x. View

11.

Hashikawa K, Hashikawa Y, Lischinsky J, Lin D . The Neural Mechanisms of Sexually Dimorphic Aggressive Behaviors. Trends Genet. 2018; 34(10):755-776. DOI: 10.1016/j.tig.2018.07.001. View

12.

Champagne F, Francis D, Mar A, Meaney M . Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol Behav. 2003; 79(3):359-71. DOI: 10.1016/s0031-9384(03)00149-5. View

13.

Wright J, Dietrich K, Ris M, Hornung R, Wessel S, Lanphear B . Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. PLoS Med. 2008; 5(5):e101. PMC: 2689664. DOI: 10.1371/journal.pmed.0050101. View

14.

Canfield R, Kreher D, Cornwell C, Henderson Jr C . Low-level lead exposure, executive functioning, and learning in early childhood. Child Neuropsychol. 2003; 9(1):35-53. DOI: 10.1076/chin.9.1.35.14496. View

15.

Anderson D, Pothakos K, Schneider J . Sex and rearing condition modify the effects of perinatal lead exposure on learning and memory. Neurotoxicology. 2012; 33(5):985-95. PMC: 3430807. DOI: 10.1016/j.neuro.2012.04.016. View

16.

Blanchard R, Blanchard D . Aggressive behavior in the rat. Behav Biol. 1977; 21(2):197-224. DOI: 10.1016/s0091-6773(77)90308-x. View

17.

Brockel B, Cory-Slechta D . Lead, attention, and impulsive behavior: changes in a fixed-ratio waiting-for-reward paradigm. Pharmacol Biochem Behav. 1998; 60(2):545-52. DOI: 10.1016/s0091-3057(98)00023-9. View

18.

Bedrosian T, Quayle C, Novaresi N, Gage F . Early life experience drives structural variation of neural genomes in mice. Science. 2018; 359(6382):1395-1399. DOI: 10.1126/science.aah3378. View

19.

White B, Bonilha H, Ellis Jr C . Racial/Ethnic Differences in Childhood Blood Lead Levels Among Children <72 Months of Age in the United States: a Systematic Review of the Literature. J Racial Ethn Health Disparities. 2016; 3(1):145-53. DOI: 10.1007/s40615-015-0124-9. View

20.

Berton O, McClung C, DiLeone R, Krishnan V, Renthal W, Russo S . Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006; 311(5762):864-8. DOI: 10.1126/science.1120972. View