STAT1 and STAT4 Expression As Prognostic Biomarkers in Patients with Bladder Cancer

Overview

Journal Mol Clin Oncol

Specialty Oncology

Date 2025 Feb 24

PMID 39989605

Authors

Hajar El Ahanidi

Meryem El Azzouzi

Boutaina Addoum

Mohammed Tetou

Ilyass Hassan

Abderrahmane Al Bouzidi

Mohammed Oukabli

Chaimae Hafidi Alaoui

Imane Chaoui

Laila Benbacer

Mohammed El Mzibri

Ahmed Ameur

Camilla Jandus

Mohammed Attaleb

Affiliations

Soon will be listed here.

Abstract

Signal transducer and activator of transcription (STAT) proteins are cytoplasmic transcription factors known to play key roles in numerous physiological and pathological processes, from pathogen response to cancer modulation. However, the roles of some STAT family members, particularly STAT1 and STAT4, in the initiation and progression of bladder cancer (BC) have not been comprehensively studied. The present study investigated the expression pattern of STAT1 and STAT4 in the prognosis and survival of BC taking advantage of patients' specimens and cell lines. In our cohort, high mRNA expression of STAT1 was significantly associated with tumor invasiveness, recurrence and progression, and was shown to increase according to tumor stage in BC cell lines. However, it did not affect patient survival. By contrast, STAT4 exhibited its highest expression in early-stage tumors, without a significant link to the tumor stage. Moreover, it was found that increased STAT4 mRNA expression was associated with improved disease-free survival and overall survival in our cohort. Collectively, these findings suggest that STAT1 and STAT4 could be promising prognostic markers to enhance BC management.

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