Hypertension Inhibition by Dubosiella Newyorkensis Via Reducing Pentosidine Synthesis

Overview

Journal NPJ Biofilms Microbiomes

Date 2025 Feb 22

PMID 39987250

Authors

Tian-Hao Liu

Ming-Hao Chen

Chen-Yang Zhang

Ting Xie

Sitong Zhang

Haining Hao

Zhen-Yu Bai

Yu-Zheng Xue

Jiong-Wei Wang

Ya Xiao

Hong Wei

Li-Guo Chen

Affiliations

Soon will be listed here.

Abstract

Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in response to HSD in both metabolic modes. Supplement of pentosidine, deteriorated hypertension and vascular endothelial damage. Differential genes enriched in the glycerophospholipid metabolism were markedly altered in cultured bacteria. Our study has identified Dubosiella newyorkensis as a new salt-sensitive gut microbe that inhibits pentosidine production thereby alleviating hypertension.

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