Low-density Plasmodium Falciparum Infection: "Even a Parasite Will Turn"

As global malaria control and elimination efforts have resulted in the suppression of Plasmodium falciparum infections, low-density Plasmodium falciparum infections present a significant challenge. These infections, frequently characterized as "submicroscopic" or "asymptomatic", contribute to the persistent transmission in endemic regions. Recent advancements in molecular diagnostic methodologies have enhanced the detection of these infections and elucidated the nature of previously unrecognized infections. These infections harbor smaller populations of parasites; however, the risk of disease progression and transmission remains substantial. The observed infections could be an alternative survival mechanism of this parasite. Thus, control measures should be redesigned to address these infections, rather than merely expanding the current tools. This review provides an overview of the issues surrounding the detection and monitoring of these infections and their importance for infected individuals and populations, with further emphasis on control measures for malaria elimination.