Navigating Neural Pathways: How Stimulation Polarity Shapes Deep Brain Stimulation Efficacy

Overview

Journal Brain Commun

Publisher Oxford University Press

Specialty Neurology

Date 2025 Feb 21

PMID 39980738

Authors

Atefeh Asadi

Nabin Koirala

Muthuraman Muthuraman

Affiliations

Soon will be listed here.

Abstract

This scientific commentary refers to 'Neural pathway activation in the subthalamic region depends on stimulation polarity' by Borgheai . (https://doi.org/10.1093/braincomms/fcaf006).

References

Borgheai S, Opri E, Isbaine F, Cole E, Jafari Deligani R, Laxpati N . Neural pathway activation in the subthalamic region depends on stimulation polarity. Brain Commun. 2025; 7(1):fcaf006. PMC: 11839843. DOI: 10.1093/braincomms/fcaf006. View

Nambu A, Tokuno H, Takada M . Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway. Neurosci Res. 2002; 43(2):111-7. DOI: 10.1016/s0168-0102(02)00027-5. View

Gradinaru V, Mogri M, Thompson K, Henderson J, Deisseroth K . Optical deconstruction of parkinsonian neural circuitry. Science. 2009; 324(5925):354-9. PMC: 6744370. DOI: 10.1126/science.1167093. View

McGregor M, Nelson A . Circuit Mechanisms of Parkinson's Disease. Neuron. 2019; 101(6):1042-1056. DOI: 10.1016/j.neuron.2019.03.004. View

Monakow K, Akert K, Kunzle H . Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey. Exp Brain Res. 1978; 33(3-4):395-403. DOI: 10.1007/BF00235561. View

Herve D, Rogard M, Levi-Strauss M . Molecular analysis of the multiple Golf alpha subunit mRNAs in the rat brain. Brain Res Mol Brain Res. 1995; 32(1):125-34. DOI: 10.1016/0169-328x(95)00070-9. View

Calabresi P, Picconi B, Tozzi A, Ghiglieri V, Di Filippo M . Direct and indirect pathways of basal ganglia: a critical reappraisal. Nat Neurosci. 2014; 17(8):1022-30. DOI: 10.1038/nn.3743. View

Gerfen C, Engber T, Mahan L, Susel Z, Chase T, Monsma Jr F . D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science. 1990; 250(4986):1429-32. DOI: 10.1126/science.2147780. View

Albin R, Young A, Penney J . The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989; 12(10):366-75. DOI: 10.1016/0166-2236(89)90074-x. View

10.

Timmermann L, Wojtecki L, Gross J, Lehrke R, Voges J, Maarouf M . Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease. Mov Disord. 2004; 19(11):1328-33. DOI: 10.1002/mds.20198. View

11.

Muthuraman M, Palotai M, Javor-Duray B, Kelemen A, Koirala N, Halasz L . Frequency-specific network activity predicts bradykinesia severity in Parkinson's disease. Neuroimage Clin. 2021; 32:102857. PMC: 8526781. DOI: 10.1016/j.nicl.2021.102857. View