Mutations of Affect Susceptibility to Biofilms

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2025 Feb 20

PMID 39975509

Authors

Jonathan Hodgkin

Dave Stroud

Delia ORourke

Affiliations

Soon will be listed here.

Abstract

The transcription factor NHR-49 has been extensively studied for its functions in regulating metabolic processes, stress responses, innate immunity and aging. Molecular identification of a gene previously known as , which affects susceptibility of worms to deleterious surface attachment of bacterial biofilms from revealed that is an ochre nonsense allele of . Other severe mutations of also had a Bah phenotype, but deletions affecting 5' isoforms of the gene did not affect biofilm attachment, nor did 3' gain-of-function missense mutations. Other genes ( ) encode GT92 glycosylation factors, predicted to affect surface coat. NHR-49 may act as a positive transcription factor for one or more of these surface glycosylation genes, in contrast to its other roles in regulating metabolic processes.

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