Chemoresistance Mechanisms to 5-Fluorouracil and Reversal Strategies in Lung and Breast Cancer

Overview

Journal Sci Rep

Specialty Science

Date 2025 Feb 19

PMID 39972013

Authors

Chunge Zhong

Shengnan Wang

Wen-Jie Jiang

Zexu Li

Xiaofeng Wang

Shuangshuang Fan

Jun Huang

Hua-Jun Wu

Ren Sheng

Teng Fei

Affiliations

Soon will be listed here.

Abstract

Chemotherapy drug 5-Fluorouracil (5-FU) is a major treatment for many cancers; however, its efficacy is limited by chemoresistance. Here, we investigate the resistance mechanisms to 5-FU and reversal strategies in lung and breast cancer cells. Using multiple 5-FU-resistant lung cancer and breast cancer cell models, we reveal differential cellular and molecular features of 5-FU resistance between different cancer types. We further unravel the implications of immune-related processes, NOTCH and WNT signaling with 5-FU resistance. In lung cancer, the activation of WNT/β-catenin signaling promotes the resistance and blocking this signaling re-sensitizes resistant cells to 5-FU treatment. Our study not only reveals differential features and mechanisms underlying 5-FU resistance across different cancers, but also suggests potential strategies against such resistance.

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