Donor Modulation Brings All-in-one Phototheranostics for NIR-II Imaging-guided Type-I Photodynamic/photothermal Synergistic Cancer Therapy

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2025 Feb 19

PMID 39968281

Authors

Yuxin Ren

Xinyi Zhang

Ling Li

Qiong Yuan

Benkai Bao

Meiqi Li

Yanli Tang

Affiliations

Soon will be listed here.

Abstract

Type-I photodynamic (PDT) and photothermal (PTT) synergistic therapy guided by fluorescence imaging in the near-infrared region II (NIR-II) is crucial for cancer diagnosis and treatment. Phototheranostics provide a promising system for efficient imaging-guided phototherapy, combining diagnostics with therapeutics within a single photosensitizer and avoiding the complexity of composition and low reproducibility of combination methods. Herein, we design and synthesize an all-in-one phototheranostic agent OTAB by modifying aza-BODIPY with a methoxy group substituted triphenylamine moiety, followed by the formation of nanoparticle OTAB@cRGD NPs self-assembly with DSPE-PEG-cRGD. Structurally, the methoxy-modified triphenylamine moiety as a strong electron donor can reduce the singlet-triplet energy gap (Δ ) by creating a strong intramolecular charge transfer state, thereby accelerating the intersystem crossing process and thus preferentially generating O˙ electron transfer. A single 808 nm laser can trigger its NIR-II imaging and excellent type-I photodynamic and photothermal therapy. Furthermore, OTAB@cRGD NPs with high photostability, colloid stability and biocompatibility can actively target tumor tissue intravenous injection. Thus, tumor localization and imaging diagnosis are successfully realized. The PDT/PTT synergistic therapy brings efficient tumor inhibition and ablation both and . Therefore, this work provides a new strategy to construct an all-in-one multifunctional probe for the integration of NIR-II diagnosis and treatment.

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