Fungal Protein D1 Inhibits the Proliferation of A549 Cells Via Activating the P53/miR-34a Signaling Pathway

Overview

Journal J Nat Med

Publisher Springer

Date 2025 Feb 18

PMID 39966243

Authors

Min-Hui Zhang

Fang Liu

Wen-Hui Gao

Zhao-Kun Liu

Affiliations

Soon will be listed here.

Abstract

Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 from B. bicolor, and found that protein D1 has a significant inhibitory effect on the growth and proliferation of lung cancer A549 cells both in vitro and in vivo. In this paper, we found that miR-34a plays an important role in inhibiting the proliferation of A549 cells. miR-34a is the functional target of protein D1 against A549 cells. Protein D1 induces the positive feedback regulation of miR-34a and p53, which further regulates downstream Bcl-2 and CDK6, and inhibits the proliferation of A549 cells.

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