Maternal and Neonatal Efficacy and Safety Outcomes of Myo-Inositol in Women With or at High Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Overview

Journal Diabetes Spectr

Specialty Endocrinology

Date 2025 Feb 17

PMID 39959527

Authors

Youssef Ahmed Ali

Muhannad Sharara

Mostafa Mahrous

Abdelrahman Alaa Rezk

Ahmed Abuali

Mohamed Aly Seoudy

Mohamed Yousif Elnaghy

Ahmed Elsayed Elsekaily

Mohammed Elsayed Elkholy

Khaled Mohamed Ragab

Marwa Mohamed Badawy

Ibrahim Kamal

Ahmed Hashem Fathallah

Affiliations

Soon will be listed here.

References

Kulshrestha V, Balani S, Kachhawa G, Vanamail P, Kumari R, Sharma J . Efficacy of myoinositol in treatment of gestational diabetes mellitus in Asian Indian women: A pilot randomized clinical trial. Eur J Obstet Gynecol Reprod Biol. 2021; 260:42-47. DOI: 10.1016/j.ejogrb.2021.02.017. View

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

Zhang Y, Wang Z, Liu B, Cai J . Pregnancy outcome of overweight and obese Chinese women with gestational diabetes. J Obstet Gynaecol. 2014; 34(8):662-5. DOI: 10.3109/01443615.2014.920787. View

Laitinen K, Poussa T, Isolauri E . Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr. 2008; 101(11):1679-87. DOI: 10.1017/S0007114508111461. View

Lubin V, Shojai R, Darmon P, Cosson E . A pilot study of gestational diabetes mellitus not controlled by diet alone: First-line medical treatment with myoinositol may limit the need for insulin. Diabetes Metab. 2016; 42(3):192-5. DOI: 10.1016/j.diabet.2016.01.005. View

Phelps R, Metzger B, Freinkel N . Carbohydrate metabolism in pregnancy. XVII. Diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol, and individual amino acids in late normal pregnancy. Am J Obstet Gynecol. 1981; 140(7):730-6. View

Scioscia M, Kunjara S, Gumaa K, McLean P, Rodeck C, Rademacher T . Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus. Diabet Med. 2007; 24(11):1300-4. DOI: 10.1111/j.1464-5491.2007.02267.x. View

Staat B, Galan H, Harwood J, Lee G, Marconi A, Paolini C . Transplacental supply of mannose and inositol in uncomplicated pregnancies using stable isotopes. J Clin Endocrinol Metab. 2012; 97(7):2497-502. PMC: 3387389. DOI: 10.1210/jc.2011-1800. View

Ben-Haroush A, Yogev Y, Hod M . Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med. 2004; 21(2):103-13. DOI: 10.1046/j.1464-5491.2003.00985.x. View

10.

Corrado F, DAnna R, Di Vieste G, Giordano D, Pintaudi B, Santamaria A . The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Diabet Med. 2011; 28(8):972-5. DOI: 10.1111/j.1464-5491.2011.03284.x. View

11.

Crowther C, Hiller J, Moss J, McPhee A, Jeffries W, Robinson J . Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005; 352(24):2477-86. DOI: 10.1056/NEJMoa042973. View

12.

Santamaria A, Di Benedetto A, Petrella E, Pintaudi B, Corrado F, DAnna R . Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. J Matern Fetal Neonatal Med. 2015; 29(19):3234-7. DOI: 10.3109/14767058.2015.1121478. View

13.

. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes. 2008; 58(2):453-9. PMC: 2628620. DOI: 10.2337/db08-1112. View

14.

Metzger B, Lowe L, Dyer A, Trimble E, Chaovarindr U, Coustan D . Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008; 358(19):1991-2002. DOI: 10.1056/NEJMoa0707943. View

15.

. 2. Classification and Diagnosis of Diabetes: . Diabetes Care. 2019; 43(Suppl 1):S14-S31. DOI: 10.2337/dc20-S002. View

16.

Giordano D, Corrado F, Santamaria A, Quattrone S, Pintaudi B, Di Benedetto A . Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2010; 18(1):102-4. DOI: 10.1097/gme.0b013e3181e8e1b1. View

17.

Coustan D . Can a dietary supplement prevent gestational diabetes mellitus?. Diabetes Care. 2013; 36(4):777-9. PMC: 3609500. DOI: 10.2337/dc12-2505. View

18.

Genazzani A, Lanzoni C, Ricchieri F, Jasonni V . Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol. 2008; 24(3):139-44. DOI: 10.1080/09513590801893232. View

19.

Facchinetti F, Dante G, Petrella E, Neri I . Dietary interventions, lifestyle changes, and dietary supplements in preventing gestational diabetes mellitus: a literature review. Obstet Gynecol Surv. 2014; 69(11):669-80. DOI: 10.1097/OGX.0000000000000121. View

20.

Rowan J, Rush E, Plank L, Lu J, Obolonkin V, Coat S . Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care. 2018; 6(1):e000456. PMC: 5905785. DOI: 10.1136/bmjdrc-2017-000456. View