» Articles » PMID: 39959336

SERUM ACTIVITY OF ANTIOXIDATIVE ENZYMES AND CONCENTRATION OF MALONDIALDEHYDE AS PREDICTORS OF COLORECTAL CANCER STAGE IN CROATIAN PATIENTS

Overview
Journal Acta Clin Croat
Specialty General Medicine
Date 2025 Feb 17
PMID 39959336
Authors
Affiliations
Soon will be listed here.
Abstract

One of the factors involved in the colorectal cancer development is intracellular oxidative stress and antioxidative imbalance. The study aimed to explore the link between oxidative stress measured by the activity of antioxidative markers and lipid peroxidation product malondialdehyde (MDA) as possible cancer predictors of colorectal cancer by using several statistical methods. The study included 50 adult colorectal cancer patients of both genders. MDA level, the activity of antioxidative markers superoxide dismutase and catalase, and glutathione concentration were determined in patient sera. There was no age difference between male and female patients (p=0.579), and no gender differences according to cancer site (p=0.995), stage (p=0.083), and size (p=0.245). There were no differences in the levels of studied enzymes. Correlation analysis of antioxidative markers and MDA with cancer size and patient age revealed strongest individual correlation between the MDA and cancer size variables (r=-0.56).

References
1.
Gopcevic K, Rovcanin B, Tatic S, Krivokapic Z, Gajic M, Dragutinovic V . Activity of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in different stages of colorectal carcinoma. Dig Dis Sci. 2013; 58(9):2646-52. DOI: 10.1007/s10620-013-2681-2. View

2.
Jayakumar T, Sakthivel M, Thomas P, Geraldine P . Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. Chem Biol Interact. 2008; 176(2-3):108-20. DOI: 10.1016/j.cbi.2008.08.006. View

3.
Ljubicic N, Poropat G, Antoljak N, Basic Markovic N, Amerl Sakic V, Rada M . OPPORTUNISTIC SCREENING FOR COLORECTAL CANCER IN HIGH-RISK PATIENTS IN FAMILY MEDICINE PRACTICES IN THE REPUBLIC OF CROATIA. Acta Clin Croat. 2022; 60(Suppl 2):17-26. PMC: 9036274. DOI: 10.20471/acc.2021.60.s2.01. View

4.
Li R, Jia Z, Trush M . Defining ROS in Biology and Medicine. React Oxyg Species (Apex). 2018; 1(1):9-21. PMC: 5921829. DOI: 10.20455/ros.2016.803. View

5.
Carini F, Mazzola M, Rappa F, Jurjus A, Gerges Geagea A, Al Kattar S . Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants. Anticancer Res. 2017; 37(9):4759-4766. DOI: 10.21873/anticanres.11882. View