Uptake and Release Kinetics Longevity in Stimuli-Responsive Hydrogels for Hydrophilic Drug Therapy

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2025 Feb 17

PMID 39959097

Authors

Parker M Toews

Jeffrey S Bates

Affiliations

Soon will be listed here.

Abstract

The uptake and release of target molecules were studied in hydrogels as a function of time over a month to determine what, if any, deviation exists in these properties. Through the use of spectroscopic techniques such as FT-IR and UV-vis-NIR in combination with drug release kinetics and swelling kinetics studies, both the effect of imprinting and the effect of time could be substantially analyzed for hydrogels. Molecular imprinting provides a significant advantage over nonimprinted hydrogel samples through the sustainment of a first-order release profile throughout the month without significant deviations in the releasable concentration, while nonimprinted samples struggle in their capability to be consistently load-cycled. Changes between the imprinted and nonimprinted samples are not evidenced to be significant chemical deviations; rather, they are attributable to functionality differences between the release mechanisms of these hydrogels.

References

Bayer I . Controlled Drug Release from Nanoengineered Polysaccharides. Pharmaceutics. 2023; 15(5). PMC: 10221078. DOI: 10.3390/pharmaceutics15051364. View

Andrews P, Craik D, Martin J . Functional group contributions to drug-receptor interactions. J Med Chem. 1984; 27(12):1648-57. DOI: 10.1021/jm00378a021. View

Ko J, Kim C, Kim D, Song Y, Lee S, Yeom B . High-performance electrified hydrogel actuators based on wrinkled nanomembrane electrodes for untethered insect-scale soft aquabots. Sci Robot. 2022; 7(71):eabo6463. DOI: 10.1126/scirobotics.abo6463. View

McDonald H, Garg A, Haynes R . Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA. 2002; 288(22):2868-79. DOI: 10.1001/jama.288.22.2868. View

Zhang C, Zhou Y, Han H, Zheng H, Xu W, Wang Z . Dopamine-Triggered Hydrogels with High Transparency, Self-Adhesion, and Thermoresponse as Skinlike Sensors. ACS Nano. 2021; 15(1):1785-1794. DOI: 10.1021/acsnano.0c09577. View

Tseng S . Evaluation of the ocular surface in dry-eye conditions. Int Ophthalmol Clin. 1994; 34(1):57-69. DOI: 10.1097/00004397-199403410-00007. View

Hu X, Vatankhah-Varnoosfaderani M, Zhou J, Li Q, Sheiko S . Weak Hydrogen Bonding Enables Hard, Strong, Tough, and Elastic Hydrogels. Adv Mater. 2015; 27(43):6899-905. DOI: 10.1002/adma.201503724. View

Key J . Development of contact lenses and their worldwide use. Eye Contact Lens. 2007; 33(6 Pt 2):343-5. DOI: 10.1097/ICL.0b013e318157c230. View

Bodoki A, Iacob B, Dinte E, Vostinaru O, Samoila O, Bodoki E . Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Ocular Therapy. Polymers (Basel). 2021; 13(21). PMC: 8588458. DOI: 10.3390/polym13213649. View

10.

Hiratani H, Fujiwara A, Tamiya Y, Mizutani Y, Alvarez-Lorenzo C . Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials. 2004; 26(11):1293-8. DOI: 10.1016/j.biomaterials.2004.04.030. View

11.

Li H, Liu Y, He X, Ding Y, Yan H, Xie P . [Electrospinning technology in tissue engineering scaffolds]. Sheng Wu Gong Cheng Xue Bao. 2012; 28(1):15-25. View

12.

Quaranta L, Novella A, Tettamanti M, Pasina L, Weinreb R, Nobili A . Adherence and Persistence to Medical Therapy in Glaucoma: An Overview. Ophthalmol Ther. 2023; 12(5):2227-2240. PMC: 10441906. DOI: 10.1007/s40123-023-00730-z. View

13.

Uchino M, Yokoi N, Shimazaki J, Hori Y, Tsubota K, The Japan Dry Eye Society . Adherence to Eye Drops Usage in Dry Eye Patients and Reasons for Non-Compliance: A Web-Based Survey. J Clin Med. 2022; 11(2). PMC: 8779746. DOI: 10.3390/jcm11020367. View

14.

Hsu E, Desai M . Glaucoma and Systemic Disease. Life (Basel). 2023; 13(4). PMC: 10143901. DOI: 10.3390/life13041018. View

15.

Liu F, Baudys M, Kim S . Effect of molecular weight and polydispersity on kinetics of dissolution and release from ph/temperature-sensitive polymers. J Biomater Sci Polym Ed. 1999; 10(10):1149-61. DOI: 10.1163/156856299x00739. View

16.

Ho T, Chang C, Chan H, Chung T, Shu C, Chuang K . Hydrogels: Properties and Applications in Biomedicine. Molecules. 2022; 27(9). PMC: 9104731. DOI: 10.3390/molecules27092902. View

17.

Hennink W, van Nostrum C . Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev. 2002; 54(1):13-36. DOI: 10.1016/s0169-409x(01)00240-x. View

18.

Adler G . Cross-linking of Polymers by Radiation. Science. 1963; 141(3578):321-9. DOI: 10.1126/science.141.3578.321. View

19.

Radulescu D, Neacsu I, Grumezescu A, Andronescu E . New Insights of Scaffolds Based on Hydrogels in Tissue Engineering. Polymers (Basel). 2022; 14(4). PMC: 8875010. DOI: 10.3390/polym14040799. View

20.

Abdi B, Mofidfar M, Hassanpour F, Kirbas Cilingir E, Kalajahi S, Milani P . Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery. Int J Pharm. 2023; 638:122740. DOI: 10.1016/j.ijpharm.2023.122740. View