» Articles » PMID: 39958201

Expert Consensus on Liver Transplantation Perioperative Evaluation and Rehabilitation for Acute-on-chronic Liver Failure

Overview
Journal Liver Res
Date 2025 Feb 17
PMID 39958201
Authors
Affiliations
Soon will be listed here.
Abstract

Acute-on-chronic liver failure (ACLF) can be cured by liver transplantation; however, perioperative complications still affect posttransplant outcomes. In recent years, early rehabilitation for critical illness, liver disease, and surgery have significantly improved organ reserve function, surgery tolerance, and postoperative quality of life. They could also be applied in the perioperative period of liver transplantation in patients with ACLF. Therefore, the Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association, the Organ Transplant Committee of China Association Rehabilitation Medicine, and the Guangdong Medical Doctor Association of Organ Transplantation conducted a comprehensive review of rehabilitation in end-stage liver disease, critical illness and surgical patients by summarizing current evidence and best clinical practices and proposed a practice consensus on evaluation of cardiopulmonary and physical function, rehabilitation or physiotherapies, as well as the safety concerns in perioperative liver transplant recipients. It will be a valuable resource for hepatologists, transplant surgeons, and intensivists as they care for ACLF patients during transplantation.

References
1.
Barberan-Garcia A, Ubre M, Roca J, Lacy A, Burgos F, Risco R . Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery: A Randomized Blinded Controlled Trial. Ann Surg. 2017; 267(1):50-56. DOI: 10.1097/SLA.0000000000002293. View

2.
Chayanupatkul M, Liangpunsakul S . Cirrhotic cardiomyopathy: review of pathophysiology and treatment. Hepatol Int. 2014; 8(3):308-15. PMC: 4160726. DOI: 10.1007/s12072-014-9531-y. View

3.
Liotta E, Romanova A, Lizza B, Rasmussen-Torvik L, Kim M, Francis B . Osmotic Shifts, Cerebral Edema, and Neurologic Deterioration in Severe Hepatic Encephalopathy. Crit Care Med. 2018; 46(2):280-289. PMC: 5774236. DOI: 10.1097/CCM.0000000000002831. View

4.
Martin P, DiMartini A, Feng S, Brown Jr R, Fallon M . Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology. 2014; 59(3):1144-65. DOI: 10.1002/hep.26972. View

5.
Mandell M, Stoner T, Barnett R, Shaked A, Bellamy M, Biancofiore G . A multicenter evaluation of safety of early extubation in liver transplant recipients. Liver Transpl. 2007; 13(11):1557-63. DOI: 10.1002/lt.21263. View