Interleaved Whole Brain Na-MRI and P-MRSI Acquisitions at 7 Tesla

Overview

Journal NMR Biomed

Publisher Wiley

Date 2025 Feb 16

PMID 39956139

Authors

Zahra Shams

Jiying Dai

Mark W J Gosselink

Hans J M Hoogduin

Wybe J M van der Kemp

Fredy Visser

Dennis W J Klomp

Jannie P Wijnen

Evita C Wiegers

Affiliations

Soon will be listed here.

Abstract

Non-H nuclei magnetic resonance spectroscopy (MRS) offers insights into metabolism, which may aid for example early stages of disease diagnosis, tissue characterization or therapy response evaluation. Sodium MRI can provide valuable information about tissue health and cellular function. When combined with P MR spectroscopic imaging (MRSI), complementary metabolic information on energy metabolism and cell proliferation can be obtained. However, sensitivity challenges stemming from low natural abundances and low gyromagnetic ratios of different nuclei have hindered progress. Besides, due to hardware constraints, different nuclei are often studied separately, and the need for dedicated hardware for x-nuclei imaging hampers clinical efficiency and patient-friendly assessments. This work introduces an interleaved acquisition scheme for 3D P-MRSI and 3D radial Na-MR imaging (Na-MRI) at 7 Tesla (7T) and demonstrates the feasibility of interleaving these two nuclei acquisitions. The interleaved protocol effectively merged P-MRSI with Na-MRI, while remaining within specific absorption rate (SAR) limits. Results revealed comparable signal-to-noise ratios (SNRs) and spectral quality between interleaved and non-interleaved scans, highlighting the approach's efficiency without compromising data quality.

References

Huhn K, Engelhorn T, Linker R, Nagel A . Potential of Sodium MRI as a Biomarker for Neurodegeneration and Neuroinflammation in Multiple Sclerosis. Front Neurol. 2019; 10:84. PMC: 6378293. DOI: 10.3389/fneur.2019.00084. View

Korzowski A, Weinfurtner N, Mueller S, Breitling J, Goerke S, Schlemmer H . Volumetric mapping of intra- and extracellular pH in the human brain using P MRSI at 7T. Magn Reson Med. 2020; 84(4):1707-1723. DOI: 10.1002/mrm.28255. View

Korzowski A, Weckesser N, Franke V, Breitling J, Goerke S, Schlemmer H . Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution P MRSI at 7T. Front Neurol. 2022; 12:735071. PMC: 8733158. DOI: 10.3389/fneur.2021.735071. View

Friedman S, Jensen J, Frederick B, Artru A, Renshaw P, Dager S . Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T. J Cereb Blood Flow Metab. 2006; 27(3):646-53. DOI: 10.1038/sj.jcbfm.9600383. View

Paech D, Regnery S, Platt T, Behl N, Weckesser N, Windisch P . Assessment of Sodium MRI at 7 Tesla as Predictor of Therapy Response and Survival in Glioblastoma Patients. Front Neurosci. 2021; 15:782516. PMC: 8671745. DOI: 10.3389/fnins.2021.782516. View

Kaggie J, Sapkota N, Thapa B, Jeong K, Shi X, Morrell G . Synchronous Radial H and Na Dual-Nuclear MRI on a Clinical MRI System, Equipped With a Broadband Transmit Channel. Concepts Magn Reson Part B Magn Reson Eng. 2019; 46B(4):191-201. PMC: 6710097. DOI: 10.1002/cmr.b.21347. View

Wild J, Marshall H, Xu X, Norquay G, Parnell S, Clemence M . Simultaneous imaging of lung structure and function with triple-nuclear hybrid MR imaging. Radiology. 2012; 267(1):251-5. DOI: 10.1148/radiol.12121153. View

Purvis L, Clarke W, Biasiolli L, Valkovic L, Robson M, Rodgers C . OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB. PLoS One. 2017; 12(9):e0185356. PMC: 5609763. DOI: 10.1371/journal.pone.0185356. View

Froeling M, Prompers J, Klomp D, van der Velden T . PCA denoising and Wiener deconvolution of P 3D CSI data to enhance effective SNR and improve point spread function. Magn Reson Med. 2021; 85(6):2992-3009. PMC: 7986807. DOI: 10.1002/mrm.28654. View

10.

Niess F, Schmid A, Bogner W, Wolzt M, Carlier P, Trattnig S . Interleaved P MRS/ H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T. Magn Reson Med. 2019; 83(6):1909-1919. PMC: 7065182. DOI: 10.1002/mrm.28088. View

11.

Hendriks A, van der Kemp W, Luijten P, Petridou N, Klomp D . SNR optimized P functional MRS to detect mitochondrial and extracellular pH change during visual stimulation. NMR Biomed. 2019; 32(11):e4137. PMC: 6900119. DOI: 10.1002/nbm.4137. View

12.

Smith M, Peterson E, Gordon J, Niles D, Rowland I, Kurpad K . In vivo imaging and spectroscopy of dynamic metabolism using simultaneous 13C and 1H MRI. IEEE Trans Biomed Eng. 2011; 59(1):45-9. PMC: 3676651. DOI: 10.1109/TBME.2011.2161988. View

13.

Lopez Kolkovsky A, Carlier P, Marty B, Meyerspeer M . Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential. NMR Biomed. 2022; 35(10):e4735. PMC: 9542607. DOI: 10.1002/nbm.4735. View

14.

Eisele P, Konstandin S, Szabo K, Ebert A, Rossmanith C, Paschke N . Temporal evolution of acute multiple sclerosis lesions on serial sodium (Na) MRI. Mult Scler Relat Disord. 2019; 29:48-54. DOI: 10.1016/j.msard.2019.01.027. View

15.

Wild J, Ajraoui S, Deppe M, Parnell S, Marshall H, Parra-Robles J . Synchronous acquisition of hyperpolarised 3He and 1H MR images of the lungs - maximising mutual anatomical and functional information. NMR Biomed. 2010; 24(2):130-4. DOI: 10.1002/nbm.1565. View

16.

SCHNALL M, Yoshizaki K, Chance B, Leigh Jr J . Triple nuclear NMR studies of cerebral metabolism during generalized seizure. Magn Reson Med. 1988; 6(1):15-23. DOI: 10.1002/mrm.1910060103. View

17.

Thulborn K, Gindin T, Davis D, Erb P . Comprehensive MR imaging protocol for stroke management: tissue sodium concentration as a measure of tissue viability in nonhuman primate studies and in clinical studies. Radiology. 1999; 213(1):156-66. DOI: 10.1148/radiology.213.1.r99se15156. View

18.

Hussain M, Stobbe R, Bhagat Y, Emery D, Butcher K, Manawadu D . Sodium imaging intensity increases with time after human ischemic stroke. Ann Neurol. 2009; 66(1):55-62. DOI: 10.1002/ana.21648. View

19.

Mohamed S, Herrmann K, Adlung A, Paschke N, Hausner L, Frolich L . Evaluation of Sodium (Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer's Disease. In Vivo. 2021; 35(1):429-435. PMC: 7880740. DOI: 10.21873/invivo.12275. View

20.

Arias-Mendoza F, Javaid T, Stoyanova R, Brown T, Gonen O . Heteronuclear multivoxel spectroscopy of in vivo human brain: two-dimensional proton interleaved with three-dimensional 1H-decoupled phosphorus chemical shift imaging. NMR Biomed. 1996; 9(3):105-13. DOI: 10.1002/(SICI)1099-1492(199605)9:3<105::AID-NBM411>3.0.CO;2-S. View