Dysregulation of Neutrophil in Sepsis: Recent Insights and Advances

Overview

Journal Cell Commun Signal

Publisher Biomed Central

Specialties Biochemistry
Cell Biology

Date 2025 Feb 14

PMID 39953528

Authors

Ji Zhang

Yuwen Shao

Jingyi Wu

Jing Zhang

Xiangsheng Xiong

Jingjing Mao

Yunwei Wei

Changhong Miao

Hao Zhang

Affiliations

Soon will be listed here.

Abstract

Sepsis remains the leading cause of death in intensive care units. Despite newer antimicrobial and supportive therapies, specific treatments are still lacking. Neutrophils are pivotal components of the effector phase of the host immune defense against pathogens and play a crucial role in the control of infections under normal circumstances. In addition to its anti-infective effects, the dysregulation and overactivation of neutrophils may lead to severe inflammation or tissue damage and are potential mechanisms for poor prognosis in sepsis. This review focuses on recent advancements in the understanding of the functional status of neutrophils across various pathological stages of sepsis to explore the mechanisms by which neutrophils participate in sepsis progression and provide insights for the treatment of sepsis by targeting neutrophils.

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