Advancing Veterinary Oncology: Next-Generation Diagnostics for Early Cancer Detection and Clinical Implementation

Overview

Journal Animals (Basel)

Date 2025 Feb 13

PMID 39943159

Authors

Aya Hasan Alshammari

Takuya Oshiro

Umbhorn Ungkulpasvich

Junichi Yamaguchi

Masayo Morishita

Sura Abbas Khdair

Hideyuki Hatakeyama

Takaaki Hirotsu

Eric di Luccio

Affiliations

Soon will be listed here.

Abstract

Cancer is a leading cause of death among companion animals, with many cases diagnosed at advanced stages when clinical signs have appeared, and prognosis is poor. Emerging diagnostic technologies, including Artificial Intelligence (AI)-enhanced imaging, liquid biopsies, molecular diagnostics, and nematode-based screening, can improve early detection capabilities in veterinary medicine. These tools offer non-invasive or minimally invasive methods to facilitate earlier detection and treatment planning, addressing the limitations of traditional diagnostics, such as radiography and tissue biopsies. Recent advancements in comparative oncology, which leverage the biological similarities between human and companion animal cancers, underscore their translational value in improving outcomes across species. Technological advances in genomics, bioinformatics, and machine learning are driving a shift toward precision medicine, enabling earlier detection, personalized treatments, and monitoring of disease progression. Liquid biopsy testing detects circulating tumor DNA and tumor cells, providing actionable insights into tumor genetics without invasive procedures. Imaging systems enhance diagnostic precision, offering consistent and accurate tumor identification across veterinary practices, while portable innovations like -based screening provide accessible options for underserved regions. As these technologies migrate from human medicine to veterinary applications, they are poised to redefine cancer care for companion animals. This review highlights key advancements in diagnostic technologies and their application in veterinary oncology, with a focus on enhancing early detection, accessibility, and precision in cancer care. By fostering the adoption of these innovations, veterinary oncology can achieve a new standard of care, improving outcomes for both animals and humans through the lens of comparative oncology.

References

Sugimoto T, Okuda Y, Shima A, Sugiura N, Kondo N, Ishihara G . A new detection method for canine and feline cancer using the olfactory system of nematodes. Biochem Biophys Rep. 2022; 32:101332. PMC: 9469661. DOI: 10.1016/j.bbrep.2022.101332. View

Simpson S, Rizvanov A, Jeyapalan J, de Brot S, Rutland C . Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Front Vet Sci. 2022; 9:965391. PMC: 9773846. DOI: 10.3389/fvets.2022.965391. View

OKell A, Lytle K, Cohen T, Wong L, Sandford E, Rafalko J . Clinical experience with next-generation sequencing-based liquid biopsy testing for cancer detection in dogs: a review of 1,500 consecutive clinical cases. J Am Vet Med Assoc. 2023; 261(6):827-836. DOI: 10.2460/javma.22.11.0526. View

Thumser-Henner P, Nytko K, Rohrer Bley C . Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy. BMC Vet Res. 2020; 16(1):30. PMC: 6995156. DOI: 10.1186/s12917-020-2247-4. View

Pang L, Argyle D . Veterinary oncology: Biology, big data and precision medicine. Vet J. 2016; 213:38-45. DOI: 10.1016/j.tvjl.2016.03.009. View

Gutierrez-Riquelme T, Karkossa I, Schubert K, Liebscher G, Packeiser E, Nolte I . Proteomic analysis of extracellular vesicles derived from canine mammary tumour cell lines identifies protein signatures specific for disease state. BMC Vet Res. 2024; 20(1):488. PMC: 11515202. DOI: 10.1186/s12917-024-04331-1. View

Ferguson D, Henderson A, McInnes E, Lind R, Wildenhain J, Gardner P . Infrared micro-spectroscopy coupled with multivariate and machine learning techniques for cancer classification in tissue: a comparison of classification method, performance, and pre-processing technique. Analyst. 2022; 147(16):3709-3722. DOI: 10.1039/d2an00775d. View

Prasanth B, Alkhowaiter S, Sawarkar G, Dharshini B, R Baskaran A . Unlocking Early Cancer Detection: Exploring Biomarkers, Circulating DNA, and Innovative Technological Approaches. Cureus. 2024; 15(12):e51090. PMC: 10808885. DOI: 10.7759/cureus.51090. View

Pinello K, Amorim I, Pires I, Canadas-Sousa A, Catarino J, Faisca P . Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats. Vet Sci. 2022; 9(10). PMC: 9611943. DOI: 10.3390/vetsci9100535. View

10.

Fittall M, Van Loo P . Translating insights into tumor evolution to clinical practice: promises and challenges. Genome Med. 2019; 11(1):20. PMC: 6440005. DOI: 10.1186/s13073-019-0632-z. View

11.

Parissenti A, Pritzker L, Guo B, Narendrula R, Wang S, Lin L . RNA disruption indicates CHOP therapy efficacy in canine lymphoma. BMC Vet Res. 2019; 15(1):453. PMC: 6916446. DOI: 10.1186/s12917-019-2189-x. View

12.

Maekawa N, Konnai S, Nishimura M, Kagawa Y, Takagi S, Hosoya K . PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma. NPJ Precis Oncol. 2021; 5(1):10. PMC: 7881100. DOI: 10.1038/s41698-021-00147-6. View

13.

Namgong C, Kim J, Lee M, Midkiff D . Non-invasive cancer detection in canine urine through chemotaxis. Front Vet Sci. 2022; 9:932474. PMC: 9396970. DOI: 10.3389/fvets.2022.932474. View

14.

Appleby R, Basran P . Artificial intelligence in veterinary medicine. J Am Vet Med Assoc. 2022; 260(8):819-824. DOI: 10.2460/javma.22.03.0093. View

15.

Yitbarek D, Dagnaw G . Application of Advanced Imaging Modalities in Veterinary Medicine: A Review. Vet Med (Auckl). 2022; 13:117-130. PMC: 9166686. DOI: 10.2147/VMRR.S367040. View

16.

Mendez I, Van den Hof M . Mobile remote-presence devices for point-of-care health care delivery. CMAJ. 2013; 185(17):1512-6. PMC: 3832559. DOI: 10.1503/cmaj.120223. View

17.

Nascimento C, Ferreira F . Tumor microenvironment of human breast cancer, and feline mammary carcinoma as a potential study model. Biochim Biophys Acta Rev Cancer. 2021; 1876(1):188587. DOI: 10.1016/j.bbcan.2021.188587. View

18.

Nelson B . In dogged pursuit of cancer's genetic origins: researchers are using the increased cancer susceptibility within specific dog breeds to benefit both canines and humans. Cancer Cytopathol. 2014; 122(5):313-4. DOI: 10.1002/cncy.21438. View

19.

Poteet B . Veterinary teleradiology. Vet Radiol Ultrasound. 2008; 49(1 Suppl 1):S33-6. DOI: 10.1111/j.1740-8261.2007.00331.x. View

20.

London C . Tyrosine kinase inhibitors in veterinary medicine. Top Companion Anim Med. 2009; 24(3):106-12. DOI: 10.1053/j.tcam.2009.02.002. View