Comparison of the Anesthetic Effects of Alfaxalone Combined with Xylazine or Dexmedetomidine in Captive Formosa Serows ()

Overview

Journal Animals (Basel)

Date 2025 Feb 13

PMID 39943077

Authors

Li-Jen Chang

Toshitsugu Ishihara

Chen-Yeh Lien

Kuan-Sheng Chen

Affiliations

Soon will be listed here.

Abstract

Formosan serows are an endemic species in Taiwan. Alfaxalone, a γ-aminobutyric acid agonist, induces or maintains anesthesia in various veterinary species with reported potential adverse effects of respiratory depression and tachycardia. α2-Adrenoceptor agonists exert sedative and muscle relaxation effects, along with substantial cardiovascular adverse effects. Here, we aimed to evaluate the anesthetic effects of alfaxalone combined with xylazine or dexmedetomidine (AX vs. AD, respectively) in Formosan serows. In this randomized, masked study, AX was administered to four serows, and AD was administered to five serows intramuscularly via blow dart. The time and score of induction and recovery were recorded. Post-intubation, isoflurane was administered for maintenance anesthesia. Heart rate (HR), respiratory rate (RR), peripheral saturation of oxygenation (SpO), rectal temperature (RT), and end-tidal CO (EtCO) were recorded every five to eight minutes. Atipamezole and tolazoline were administered to antagonize dexmedetomidine and xylazine post-procedure, respectively. Both combinations allowed smooth induction and recovery. The AD group exhibited significantly lower HR and SpO and significantly higher RT and EtCO than the AX group (both < 0.01). The AD-treated serows exhibited notable muscle rigidity after induction and significant hypoventilation and hypoxemia during the procedure. Although alfaxalone combined with dexmedetomidine or xylazine can produce satisfactory induction and recovery in Formosa serows, notable hypoxemia and hypoventilation are induced by the alfaxalone-dexmedetomidine combination compared to the alfaxalone-xylazine combination.

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