Effect of Dietary Supplementation on the Growth Performance, Intestinal Health, Antioxidant Capacity, and MTOR Signaling Pathway of Juvenile Coho Salmon ()

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Feb 13

PMID 39940676

Authors

Qin Zhang

Lan Li

Rongxin Qin

Liuqing Meng

Dongsheng Liu

Tong Tong

Lixiao Xu

Yongqiang Liu

Weiguang Kong

Affiliations

Soon will be listed here.

Abstract

This study investigates the effect of dietary supplementation on juvenile coho salmon (). Four groups of the juveniles (initial weight 103.87 ± 2.65 g) were fed for 10 weeks with four diets containing 0 (control diet), 10 (T1), 10 (T2), and 10 (T3) cfu/g of . The main results are as follows: Compared with the control diet, the final weight, specific growth rate (SGR), and weight gain rate (WGR) of the juveniles fed the T1, T2, and T3 diet significantly ( < 0.05) increased, while the feed coefficient ratio (FCR) expressed an opposite trend. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of the juveniles fed the T2 diet significantly ( < 0.05) increased, while the malondialdehyde (MDA) expressed an opposite trend. The expression of phosphatidylinositol 4,5-bisphosphate 3-kinase (), AKT-interacting protein (), mechanistic target of rapamycin kinase (), glucose-6-phosphate dehydrogenase (), , , and genes in the liver of the juveniles fed the T2 diet significantly ( < 0.05) increased. In conclusion, the T2 diet significantly improved the growth performance, antioxidant capacity, and upregulated key mTOR pathway genes in juvenile coho salmon.

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