Non-Animal Hyaluronic Acid and Probiotics Enhance Skin Health Via the Gut-Skin Axis: An In Vitro Study on Bioavailability and Cellular Impact

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Feb 13

PMID 39940667

Authors

Rebecca Galla

Simone Mule

Sara Ferrari

Claudio Molinari

Francesca Uberti

Affiliations

Soon will be listed here.

Abstract

Hyaluronic acid (HA) represents a pivotal component of the extracellular matrix, particularly within the context of the skin. The absorption and metabolism of orally ingested HA have been extensively investigated due to the prevalence of HA-based supplements. The objective of this study was to evaluate the impact of a combination of non-animal HA and novaBLG1 on dermal health following intestinal transit. The bioavailability of the compound was evaluated using a model that reproduced the human intestinal barrier in vitro, and its biological effects were investigated on skin cells via the gut-skin axis. The results demonstrated that probiotics augmented the absorption of non-animal HA by approximately 30% in comparison to non-animal HA alone and by 82% in comparison to sodium hyaluronate. Furthermore, the combination demonstrated a notable enhancement in skin cell proliferation, with increases of 16%, 8%, and 29.7% over 144 h in comparison to non-animal hyaluronan, novaBLG1, and sodium hyaluronate, respectively. The combination was observed to positively affect all markers of skin health and well-being, achieving its goals without any adverse effects on the gut. This approach offers a novel method for enhancing skin health.

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