The Relationship Between Frailty and Major Adverse Cardiovascular and Cerebrovascular Events in Chinese Older Adults: the Mediating Effect of Lipid Accumulation Products

Overview

Journal Arch Public Health

Publisher Biomed Central

Date 2025 Feb 12

PMID 39939980

Authors

Zhoucheng Kang

Yongli Ye

Hao Xiao

Lingling Liu

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE.

Methods: This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects.

Results: Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03-1.10). Frailty directly impacted MACCE (β = 0.045, P = 0.007). Frailty had a significant effect on LAP (β = 12.21, P < 0.01), while LAP had a significant impact on MACCE (β = 11.14, p = 0.014). The mediation effect of LAP accounted for 1.7% of the total effect regarding the frailty with MACCE.

Conclusion: LAP mediate the relationship between frailty and MACCE. Our findings suggest that instructing frailty patients to have a reasonable diet and exercise to control LAP at a low level may be an effective measure to reduce MACCE.

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