Impact of Physical Exercise on the Regulation of Brain-derived Neurotrophic Factor in People with Neurodegenerative Diseases

Overview

Journal Front Neurol

Specialty Neurology

Date 2025 Feb 12

PMID 39935805

Authors

Ana Romero Garavito

Valery Diaz Martinez

Estherz Juarez Cortes

Jose Vicente Negrete Diaz

Liliana Marcela Montilla Rodriguez

Affiliations

Soon will be listed here.

Abstract

This review explores the impact of physical exercise on brain-derived neurotrophic factor (BDNF) and its relationship with neurodegenerative diseases. The key role of BDNF in maintaining brain health is highlighted, and recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults. Additionally, the interaction between the BDNF Val66Met genetic polymorphism and exercise on cognitive function is examined. The review emphasizes the possibility of exercise as a complementary therapy for neurodegenerative diseases, although further research is required to fully understand its effects.

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