Evaluation of Renal Function in Dogs Using Pulsed Doppler Ultrasonography

Overview

Journal Open Vet J

Date 2025 Feb 10

PMID 39927338

Authors

Takami Ito

Kiwamu Hanazono

Kenjirou Miyoshi

Daiji Endoh

Affiliations

Soon will be listed here.

Abstract

Background: In human medicine, efforts have been made to evaluate venous blood flow in the kidneys to diagnose renal disease and estimate renal function. In dogs, previous studies have predicted renal function using the resistive index (RI) and pulsatility index (PI), which are derived from renal arterial blood flow velocity assessed via pulsed Doppler ultrasonography. However, to date, no study has been conducted on renal venous blood flow velocity in dogs.

Aim: To investigate the relationship between renal venous blood flow velocity and renal function.

Methods: Ten normal beagle dogs underwent blood tests and glomerular filtration rate (GFR) measurements. Pulsed Doppler ultrasonography was performed under sedation to measure the maximum venous flow velocity (Vmax), minimum venous flow velocity (Vmin), and venous impedance index in the renal and interlobular veins. The RI and PI were calculated from the renal and interlobular arteries.

Results: Vmax and Vmin of the renal vein were negatively correlated with GFR in both kidneys. No significant correlations were found between other measures and GFR. These results suggest a relationship between GFR and venous flow velocity in the renal veins assessed using pulsed Doppler ultrasonography.

Conclusion: These findings demonstrate the potential of this methodology as a new tool for predicting abnormalities in the renal venous blood flow and renal congestion in dogs. Further large-scale studies and comparisons between healthy dogs and dogs with impaired renal function are needed to validate this relationship.

References

Bragato N, Borges N, Fioravanti M . B-mode and Doppler ultrasound of chronic kidney disease in dogs and cats. Vet Res Commun. 2017; 41(4):307-315. DOI: 10.1007/s11259-017-9694-9. View

Novellas R, Espada Y, Ruiz de Gopegui R . Doppler ultrasonographic estimation of renal and ocular resistive and pulsatility indices in normal dogs and cats. Vet Radiol Ultrasound. 2007; 48(1):69-73. DOI: 10.1111/j.1740-8261.2007.00206.x. View

Nishida M, Uechi M, Kono S, Harada K, Fujiwara M . Estimating glomerular filtration rate in healthy dogs using inulin without urine collection. Res Vet Sci. 2011; 93(1):398-403. DOI: 10.1016/j.rvsc.2011.08.003. View

Koo T, Li M . A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. J Chiropr Med. 2016; 15(2):155-63. PMC: 4913118. DOI: 10.1016/j.jcm.2016.02.012. View

Nelson N, Drost W, Lerche P, Bonagura J . Noninvasive estimation of central venous pressure in anesthetized dogs by measurement of hepatic venous blood flow velocity and abdominal venous diameter. Vet Radiol Ultrasound. 2010; 51(3):313-23. DOI: 10.1111/j.1740-8261.2010.01668.x. View

Mastorakou I, Lindsell D, Piepoli M, Adamopoulos S, LEDINGHAM J . Pulsatility and resistance indices in intrarenal arteries of normal adults. Abdom Imaging. 1994; 19(4):369-73. DOI: 10.1007/BF00198202. View

Iida N, Seo Y, Sai S, Machino-Ohtsuka T, Yamamoto M, Ishizu T . Clinical Implications of Intrarenal Hemodynamic Evaluation by Doppler Ultrasonography in Heart Failure. JACC Heart Fail. 2016; 4(8):674-82. DOI: 10.1016/j.jchf.2016.03.016. View

ONeill D, Elliott J, Church D, McGreevy P, Thomson P, Brodbelt D . Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival. J Vet Intern Med. 2013; 27(4):814-21. DOI: 10.1111/jvim.12090. View

Zatelli A, Roura X, DIppolito P, Berlanda M, Zini E . The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease. Open Vet J. 2016; 6(2):121-7. PMC: 4980477. DOI: 10.4314/ovj.v6i2.8. View

10.

Choi H, Won S, Chung W, Lee K, Chang D, Lee H . Effect of intravenous mannitol upon the resistive index in complete unilateral renal obstruction in dogs. J Vet Intern Med. 2003; 17(2):158-62. DOI: 10.1111/j.1939-1676.2003.tb02427.x. View

11.

Nabity M, Lees G, Boggess M, Obare E, Yerramilli M, Rakitin A . Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015; 29(4):1036-44. PMC: 4895368. DOI: 10.1111/jvim.12835. View

12.

Ronco C, Haapio M, House A, Anavekar N, Bellomo R . Cardiorenal syndrome. J Am Coll Cardiol. 2008; 52(19):1527-39. DOI: 10.1016/j.jacc.2008.07.051. View

13.

Parolini C, Noce A, Staffolani E, Giarrizzo G, Costanzi S, Splendiani G . Renal resistive index and long-term outcome in chronic nephropathies. Radiology. 2009; 252(3):888-96. DOI: 10.1148/radiol.2523080351. View

14.

McKenna M, Pelligand L, Elliott J, Cotter D, Jepson R . Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non-azotemic dogs. J Vet Intern Med. 2019; 34(1):186-194. PMC: 6979102. DOI: 10.1111/jvim.15659. View

15.

Polzin D . Evidence-based step-wise approach to managing chronic kidney disease in dogs and cats. J Vet Emerg Crit Care (San Antonio). 2013; 23(2):205-15. DOI: 10.1111/vec.12034. View

16.

Sugiura T, Wada A . Resistive index predicts renal prognosis in chronic kidney disease. Nephrol Dial Transplant. 2009; 24(9):2780-5. DOI: 10.1093/ndt/gfp121. View

17.

Kudo Y, Mikami T, Nishida M, Okada K, Kaga S, Masauzi N . Altered oscillation of Doppler-derived renal and renal interlobar venous flow velocities in hypertensive and diabetic patients. J Med Ultrason (2001). 2017; 44(4):305-314. DOI: 10.1007/s10396-017-0770-0. View

18.

Heiene R, Moe L . Pharmacokinetic aspects of measurement of glomerular filtration rate in the dog: a review. J Vet Intern Med. 1998; 12(6):401-14. DOI: 10.1111/j.1939-1676.1998.tb02143.x. View

19.

Ohta Y, Fujii K, Arima H, Matsumura K, Tsuchihashi T, Tokumoto M . Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. J Hypertens. 2005; 23(10):1905-11. DOI: 10.1097/01.hjh.0000181323.44162.01. View

20.

Meier M, Jabs W, Guthmann M, Geppert G, Aydin A, Nitschke M . Sonographic Venous Velocity Index Identifies Patients with Chronic Kidney Disease and Severe Diastolic Dysfunction. Ultrasound Int Open. 2018; 4(4):E142-E148. PMC: 6202069. DOI: 10.1055/a-0684-9483. View