The Patient Perspective on Transanal Irrigation Treatment for Low Anterior Resection Syndrome After Rectal Cancer Surgery - a Qualitative and Quantitative Study

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Date 2025 Feb 7

PMID 39920596

Authors

Boglarka Rethy

Anna Schandl

Caroline Nordenvall

Gabriella Jansson Palmer

Charlotta Bergstrom

Maria Williamson

Emil Pieniowski

Asif Johar

Pernilla Lagergren

Mirna Abraham-Nordling

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of the study was to explore long-term experiences of transanal irrigation (TAI) in patients with major low anterior resection syndrome (LARS).

Methods: The study included a qualitative and quantitative analysis of patients who developed major LARS after rectal cancer surgery between 2016 and 2019 and have undergone treatment with TAI. The patients received questionnaires. Mean scores were calculated with time-to-deterioration. Individual semi-structured interviews were performed and analyzed, according to Graneheim and Lundman with patients who performed TAI regularly for more than one year.

Results: In total 28 out of 39 patients responded to the questionnaires and 16 patients participated in the interviews. At mean 6-years follow-up, a 9.4 points difference in mean LARS score was obtained, (21.2 vs. 30.7) indicating less LARS symptoms in favor of the TAI treatment. Patients in the TAI group used less loperamide compared to the control group (36% vs. 79%). The use of bulky agents was similar. The interview text rendered into three main categories: regaining control in everyday life, need for structure and planning and becoming familiar with the procedure.

Conclusions: Treatment with TAI showed the potential to improve the quality of life of patients with major LARS. The improvements in their general well-being were valued over adjustments and time spent on TAI.

Implications For Cancer Survivors: Bowel dysfunction remains after 6-years with lower LARS scores favoring the TAI treatment. In the absence of a definitive treatment, survivors of rectal cancer coping with LARS have shown appreciation of the TAI treatment.

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